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氟替卡松和沙美特罗干粉治疗支气管哮喘患者的疗效及其对炎症因子和肺功能的影响。

Efficacy of Fluticasone and Salmeterol Dry Powder in Treating Patients with Bronchial Asthma and Its Effect on Inflammatory Factors and Pulmonary Function.

作者信息

Zhang Xiaodan, Liu Min, Mao Yuhong

机构信息

Department of Basic Disciplines, Jiangxi Health Vocational College, Nanchang, Jiangxi 330052, China.

Department of Respiratory and Critical Care Medicine, The Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.

出版信息

Evid Based Complement Alternat Med. 2022 Aug 11;2022:8555417. doi: 10.1155/2022/8555417. eCollection 2022.

Abstract

OBJECTIVE

To evaluate the efficacy of fluticasone and salmeterol dry powder in treating patients with bronchial asthma and its effects on inflammatory factors and pulmonary function.

METHODS

One hundred patients with bronchial asthma, admitted to our hospital between April 2019 and June 2020, were enrolled and assigned into two groups using the random number table method. The observation group ( = 50) received budesonide powder, and the experimental group received fluticasone and salmeterol dry powder. The two groups were compared with regard to clinical efficacy, inflammatory factors, pulmonary function, and adverse reactions.

RESULTS

In the experimental group, the total effective rate of treatment was significantly higher than that in the observation group ( < 0.05); after treatment, the levels of inflammatory factors in the experimental group were lower than those in the observation group ( < 0.05); after treatment, lung function in the experimental group was significantly higher than that in the observation group ( < 0.05); the incidence of adverse reactions in the experimental group was significantly lower than that in the observation group ( < 0.05).

CONCLUSION

Salmeterol and fluticasone powder has shown impressive clinical benefits in the treatment of bronchial asthma patients. It might be a viable approach to reduce inflammatory factors and improve pulmonary function. Moreover, its good clinical safety profile makes it a promising treatment that ought to be promoted and used widely.

摘要

目的

评估氟替卡松和沙美特罗干粉治疗支气管哮喘患者的疗效及其对炎症因子和肺功能的影响。

方法

选取2019年4月至2020年6月我院收治的100例支气管哮喘患者,采用随机数字表法分为两组。观察组(n = 50)接受布地奈德粉吸入剂,试验组接受氟替卡松和沙美特罗干粉吸入剂。比较两组的临床疗效、炎症因子、肺功能及不良反应。

结果

试验组治疗总有效率显著高于观察组(P < 0.05);治疗后,试验组炎症因子水平低于观察组(P < 0.05);治疗后,试验组肺功能显著高于观察组(P < 0.05);试验组不良反应发生率显著低于观察组(P < 0.05)。

结论

沙美特罗替卡松粉吸入剂在支气管哮喘患者治疗中显示出显著的临床疗效。它可能是一种减少炎症因子和改善肺功能的可行方法。此外,其良好的临床安全性使其成为一种值得推广和广泛应用的有前景的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d3/9388234/cf95f6ff5a47/ECAM2022-8555417.001.jpg

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