Colchester Richard J, Zhang Edward Z, Beard Paul C, Desjardins Adrien E
Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.
Wellcome/EPSRC Centre for Interventional and Surgical Sciences, 43-45 Foley Street, London, W1W 7TY, UK.
Biomed Opt Express. 2022 Jun 27;13(7):4047-4057. doi: 10.1364/BOE.459486. eCollection 2022 Jul 1.
All-optical ultrasound (OpUS), where ultrasound is both generated and received using light, has emerged as a modality well-suited to highly miniaturised applications. In this work we present a proof-of-concept OpUS transducer built onto a single optical fibre with a highly miniaturised lateral dimension (<0.8 mm). A key innovation was to use a dual-clad optical fibre (DCF) to provide multimode light for ultrasound generation and single mode light for ultrasound reception. The transducer comprised a proximal section of DCF spliced to a short section of single mode fibre (SMF). Multimode light was outcoupled at the splice joint and guided within a square capillary to provide excitation for ultrasound generation. Whilst single mode light was guided to the distal tip of the SMF to a plano-concave microresonator for ultrasound reception. The device was capable of generating ultrasound with pressures >0.4 MPa and a corresponding bandwidth >27 MHz. Concurrent ultrasound generation and reception from the transducer enabled imaging via motorised pull-back allowing image acquisition times of 4 s for an aperture of 20 mm. Image resolution was as low as ~50 µm and 190 µm in the axial and lateral extents, respectively, without the need for image reconstruction. Porcine aorta was imaged demonstrating detailed ultrasound images. The unprecedented level of miniaturisation along with the high image quality produced by this device represents a radical new paradigm for minimally invasive imaging.
全光超声(OpUS)利用光来产生和接收超声,已成为一种非常适合高度小型化应用的模态。在这项工作中,我们展示了一种构建在单根光纤上的概念验证型OpUS换能器,其横向尺寸高度小型化(<0.8毫米)。一项关键创新是使用双包层光纤(DCF)来提供用于超声产生的多模光和用于超声接收的单模光。该换能器包括一段与短段单模光纤(SMF)熔接的近端DCF。多模光在熔接处外耦合,并在方形毛细管内传导以提供超声产生的激发。而单模光则被引导至SMF的远端,到达一个平凹微谐振器用于超声接收。该装置能够产生压力>0.4 MPa且相应带宽>27 MHz的超声。换能器同时进行超声产生和接收,通过电动回拉实现成像,对于20毫米的孔径,图像采集时间为4秒。在无需图像重建的情况下,图像分辨率在轴向和横向范围分别低至约50微米和190微米。对猪主动脉进行了成像,展示了详细的超声图像。该装置前所未有的小型化水平以及所产生的高图像质量代表了微创成像的全新范式。