Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China. E-mail:
Department of General Surgery, Shanghai General Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Zool Res. 2022 Sep 18;43(5):805-812. doi: 10.24272/j.issn.2095-8137.2022.111.
The divergence and continuous evolution of plants and animals contribute to ecological diversity. Promoters and transcription factors (TFs) are key determinants of gene regulation and transcription throughout life. However, the evolutionary trajectories and relationships of promoters and TFs are still poorly understood. Here, we conducted extensive analysis of large-scale multi-omics sequences in 420 animal species and 223 plant species spanning nearly a billion years of evolutionary history. Results showed that promoter GC-content and TF isoelectric points, as features/signatures that accompany long biological evolution, exhibited increasing growth in animal cells but a decreasing trend in plant cells. Furthermore, the evolutionary trajectories of promoter and TF signatures in the animal kingdom provided further evidence that Mammalia as well as Aves evolved directly from the ancestor Reptilia. The strong correlation between promoter and TF signatures indicates that promoters and TFs formed antagonistic coevolution in the animal kingdom, but mutualistic coevolution in the plant kingdom. The distinct coevolutionary patterns potentially drive the plant-animal divergence，divergent evolution and ecological diversity.
动植物的分歧和持续进化促进了生态多样性。启动子和转录因子（TFs）是整个生命过程中基因调控和转录的关键决定因素。然而，启动子和 TFs 的进化轨迹和关系仍知之甚少。在这里，我们对跨越近 10 亿年进化历史的 420 种动物和 223 种植物的大规模多组学序列进行了广泛分析。结果表明，作为伴随长期生物进化的特征/特征，启动子 GC 含量和 TF 等电点在动物细胞中呈增长趋势，而在植物细胞中呈下降趋势。此外，动物王国中启动子和 TF 特征的进化轨迹进一步证明了哺乳动物和鸟类是直接从爬行动物祖先进化而来的。启动子和 TF 特征之间的强相关性表明，在动物王国中，启动子和 TFs 形成了拮抗协同进化，但在植物王国中则形成了互利协同进化。这种独特的协同进化模式可能推动了动植物的分歧、分化和生态多样性。
