Nagasaki Medical Center of Psychiatry, Omura, Japan.
Department of Neuropsychiatry, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Neurocase. 2022 Jun;28(3):310-313. doi: 10.1080/13554794.2022.2114838. Epub 2022 Aug 21.
In the treatment of schizophrenia, long-term pharmacotherapy with D2-receptor antagonists can induce dopamine supersensitivity psychosis (DSP). We report a male patient with schizophrenia with suspected DSP due to excessive polypharmacy. He was hospitalized for several years. Most psychotropic drugs were reduced and subsequently stopped without the exacerbation of symptoms by administering modified electroconvulsive therapy (mECT). Aripiprazole was then selected as the main drug for treatment, which was subsequently changed to the long-acting injection formulation. He was eventually discharged and returned home. Combination therapy with mECT and aripiprazole, especially the long-acting injectable formulation, may help improve and prevent DSP.
在精神分裂症的治疗中，长期使用 D2 受体拮抗剂进行药物治疗可能会引发多巴胺超敏性精神病（DSP）。我们报告了一例因药物过量而疑似发生 DSP 的精神分裂症男性患者。该患者住院多年，在未加重症状的情况下，通过改良电抽搐治疗（mECT）减少并随后停止使用大部分精神药物。随后选用阿立哌唑作为主要治疗药物，随后改为长效注射剂型。最终患者出院并返回家中。mECT 与阿立哌唑联合治疗，特别是长效注射剂型，可能有助于改善和预防 DSP。
