Department of Otolaryngology-Head and Neck Surgery, Southern Illinois University, Springfield, IL, USA.
Department of Otolaryngology-Head and Neck Surgery, John Hopkins University, Baltimore, MD, USA.
Ann Otol Rhinol Laryngol. 2023 Jul;132(7):795-799. doi: 10.1177/00034894221119613. Epub 2022 Aug 21.
To determine the natural history of cystic vestibular schwannomas (VS).
Retrospective cohort.
Single tertiary academic hospital.
Adults diagnosed with cystic VS who had at least 2 MRIs performed at least 6 months apart between 2008 and 2016 with no intervening treatment.
Volumetric growth rates of both the entire tumor and individual cystic and solid components were measured. Linear growth rate of the entire tumor was assessed using the largest diameter parallel to the petrous face at the cerebellopontine angle (CPA).
Twenty-one patients met inclusion criteria. The average volumetric growth rate of the tumor was 1.1 ± 2 (range: -1.2 to 7.8), while the average growth rate of the cystic component was 0.8 ± 1.6 (range: -0.5 to 5.3) cm/year. The CPA diameter of the tumor demonstrated an average linear growth rate of was 1.2 ± 4.4 (range: -8to 13.5) mm/year. With regards to tumor diameter, 9/21 (42.9%) remained stable, 3/21 (14.2%) decreased in size, while 9/21 (42.9%) increased in size.
Cystic tumors demonstrate a wide variability in growth rate. Larger, multi-center studies will be required to further compare this relationship to solid tumors.
确定囊性前庭神经鞘瘤（VS）的自然病程。
回顾性队列研究。
单一大专院校附属医院。
2008 年至 2016 年间，至少进行了 2 次 MRI 检查（至少间隔 6 个月），且未进行任何干预治疗的囊性 VS 成人患者。
测量整个肿瘤以及各个囊性和实性成分的体积增长率。通过测量与桥小脑角（CPA）平行的最大径，评估整个肿瘤的线性生长率。
21 例患者符合纳入标准。肿瘤的平均体积增长率为 1.1±2（范围：-1.2 至 7.8），而囊性成分的平均增长率为 0.8±1.6（范围：-0.5 至 5.3）cm/年。肿瘤的 CPA 直径的平均线性生长率为 1.2±4.4（范围：-8 至 13.5）mm/年。就肿瘤直径而言，21 例患者中有 9 例（42.9%）保持稳定，3 例（14.2%）缩小，9 例（42.9%）增大。
囊性肿瘤的生长速度差异很大。需要更大规模的多中心研究来进一步比较这种关系与实性肿瘤的关系。
