Department of Forensic Sciences, University of Health Sciences, Lahore, Pakistan.
Department of Anthropology and Ethnology, Institute of Anthropology, School of Sociology and Anthropology, Xiamen University, Xiamen, China.
Forensic Sci Med Pathol. 2023 Sep;19(3):293-302. doi: 10.1007/s12024-022-00515-z. Epub 2022 Aug 22.
Variation in facial hair is one of the most conspicuous features of facial appearance, particularly in South Asia and Middle East countries. A genome-wide association study in Latin Americans has identified multiple genetic variants at distinct loci being associated with facial hair traits including eyebrow thickness, beard thickness, and monobrow. In this pilot study, we have evaluated 16 SNPs associated with facial hair traits in 58 male individuals from the Punjabi population of Pakistan. In our sample, rs365060 in EDAR and rs12597422 in FTO showed significant association with monobrow, rs6684877 in MACF1 showed significant association with eyebrow thickness, and two SNPs in LOC105379031 (rs9654415 and rs7702331) showed significant association with beard thickness. Our results also suggest that genetic association may vary between ethnic groups and geographic regions. Although more data are needed to validate our results, our findings are of value in forensic molecular photofitting research in Pakistan.
面部毛发的变化是面部特征中最明显的特征之一，尤其是在南亚和中东国家。一项在拉丁美洲人中进行的全基因组关联研究已经确定了多个位于不同位置的遗传变异与面部毛发特征有关，包括眉毛的厚度、胡须的厚度和连眉。在这项初步研究中，我们评估了来自巴基斯坦旁遮普人群的 58 名男性个体中与面部毛发特征相关的 16 个 SNP。在我们的样本中，EDAR 中的 rs365060 和 FTO 中的 rs12597422 与连眉显著相关，MACF1 中的 rs6684877 与眉毛厚度显著相关，而 LOC105379031 中的两个 SNP(rs9654415 和 rs7702331)与胡须厚度显著相关。我们的结果还表明，遗传关联可能因种族群体和地理区域而异。尽管需要更多的数据来验证我们的结果，但我们的发现对于巴基斯坦的法医分子人像拟合研究具有价值。
