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转移性上皮样血管内皮细胞瘤病例,来源于未知原发灶,与膜性肾病和高凝状态相关。

Case of metastatic epithelioid haemangioendothelioma from an unknown primary site associated with membranous nephropathy and hypercoagulable state.

机构信息

Surgery, Saint Barnabas Medical Center, Livingston, New Jersey, USA

Surgery, Saint Barnabas Medical Center, Livingston, New Jersey, USA.

出版信息

BMJ Case Rep. 2022 Aug 22;15(8):e247253. doi: 10.1136/bcr-2021-247253.

DOI:10.1136/bcr-2021-247253
PMID:35995459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9403116/
Abstract

We report a rare case of metastatic epithelioid haemangioendothelioma from an unknown primary site presenting with axillary lymph node metastases. The patient also had a new-onset membranous glomerulonephritis and thromboembolism, which we postulate were paraneoplastic. The pathogenesis of this rare cancer, the risk of misdiagnosis and membranous glomerulonephritis as a paraneoplastic syndrome are discussed.

摘要

我们报告了一例罕见的转移性上皮样血管内皮细胞瘤,该肿瘤来源于未知原发灶,伴腋窝淋巴结转移。患者还伴有新发膜性肾小球肾炎和血栓栓塞,我们推测这是副肿瘤性的。讨论了这种罕见癌症的发病机制、误诊风险以及膜性肾小球肾炎作为副肿瘤综合征的可能性。

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Case of metastatic epithelioid haemangioendothelioma from an unknown primary site associated with membranous nephropathy and hypercoagulable state.转移性上皮样血管内皮细胞瘤病例,来源于未知原发灶,与膜性肾病和高凝状态相关。
BMJ Case Rep. 2022 Aug 22;15(8):e247253. doi: 10.1136/bcr-2021-247253.
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本文引用的文献

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Primary cutaneous epithelioid hemangioendothelioma with lymph node metastasis.原发性皮肤上皮样血管内皮瘤伴淋巴结转移。
JAAD Case Rep. 2020 Aug 6;6(11):1125-1128. doi: 10.1016/j.jdcr.2020.07.052. eCollection 2020 Nov.
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Paraneoplastic glomerular diseases and malignancies.副肿瘤性肾小球疾病与恶性肿瘤
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Thromboembolic complications in the nephrotic syndrome: pathophysiology and clinical management.肾病综合征中的血栓栓塞并发症:病理生理学与临床管理
Thromb Res. 2006;118(3):397-407. doi: 10.1016/j.thromres.2005.03.030. Epub 2005 Jun 28.
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Characteristics and outcome of membranous nephropathy in older patients.老年患者膜性肾病的特征与转归
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Renal diseases associated with malignancies.与恶性肿瘤相关的肾脏疾病。
Nephrol Dial Transplant. 2001;16 Suppl 6:13-4. doi: 10.1093/ndt/16.suppl_6.13.
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Cyclosporine in patients with steroid-resistant membranous nephropathy: a randomized trial.环孢素治疗激素抵抗型膜性肾病患者:一项随机试验。
Kidney Int. 2001 Apr;59(4):1484-90. doi: 10.1046/j.1523-1755.2001.0590041484.x.
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Membranous nephropathy and orbital malignant tumor.膜性肾病与眼眶恶性肿瘤。
Pediatr Nephrol. 2000 Jan;14(1):53-5. doi: 10.1007/s004670050013.
9
Paraneoplastic glomerulopathies: new insights into an old entity.副肿瘤性肾小球病:对一个古老疾病实体的新见解
Kidney Int. 1999 Jul;56(1):355-77. doi: 10.1046/j.1523-1755.1999.00548.x.
10
Renal biopsy in the elderly: clinicopathological correlations in 143 patients.老年患者的肾活检:143例患者的临床病理相关性
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