Neuroscience Program and Department of Psychology, Carleton College, Northfield, MN, USA.
Neuroscience Program and Department of Psychology, Carleton College, Northfield, MN, USA.
J Sex Med. 2022 Oct;19(10):1506-1516. doi: 10.1016/j.jsxm.2022.07.007. Epub 2022 Aug 20.
Laboratory paradigms that enable the female rat to control the frequency and temporal distribution of sexual stimulation are well-suited to gaining knowledge about female sexual function; however, the variety of procedures used influence the specific behaviors exhibited by female rats and bring uncertainty into the conclusions that can be drawn.
In this study, we evaluated the effects of test parameters on the display of paced mating behavior in female rats to develop better preclinical models for exploring female sexual health.
Sexually experienced, estradiol- and progesterone-primed female rats were tested under paced mating conditions to determine whether sexual behavior differed as a function of number of male partners (1 or 3; Experiment 1), the time span between receipt of an ejaculation and the next intromission (ie, the post-ejaculatory interval or PEI; Experiment 2), or the duration of ejaculations (Experiment 3).
Contact-return latency, exit latency, and withdrawal duration after mounts, intromissions, and ejaculations.
The shorter withdrawal latency after intromission and longer return latency after ejaculation observed in 30-minute paced mating tests is best attributed to the female's PEI. The duration of the PEI is a specific factor that affects the display of paced mating behavior.
Understanding of neurobiological mechanisms and sensory factors influencing sexual behavior learned from these models can be applied to studies of human female sexual health.
STRENGTHS & LIMITATIONS: Sexual motivation is indicated by analogous behaviors and supported by evolutionarily conserved systems in women and rats, meaning that animal models can be used to identify neurobiological mechanisms subserving these behaviors. Nonetheless, data related specifically to physiological effects of different mating paradigms are needed in future research.
Procedures that mimic naturalistic settings, and thus enable female sexual motivation to drive behavior, are apt for studies aimed at understanding mechanisms supporting female sexual function whereas artificially lengthening the interval between an ejaculation and subsequent intromission may provide a model to study female sexual dysfunction. Corlett AG, Frankl PR, Akindona FAB, et al. Paced Mating Behaviour Is Influenced by Duration of Female Post-Ejaculatory Interval. J Sex Med 2022;19:1506-1516.
使雌性大鼠能够控制性刺激的频率和时间分布的实验室范式非常适合获得有关雌性性功能的知识；然而，使用的各种程序会影响雌性大鼠表现出的特定行为，并使从结论中带来不确定性。
在这项研究中，我们评估了测试参数对雌性大鼠进行配种行为的影响，以开发更好的临床前模型来探索女性性健康。
对经过性经验丰富、雌激素和孕激素预处理的雌性大鼠进行配种条件下的测试，以确定性行为是否因雄性伴侣数量（1 或 3；实验 1）、射精后到下一次插入之间的时间跨度（即射精后间隔或 PEI；实验 2）或射精持续时间（实验 3）的不同而有所不同。
在 30 分钟配种测试中，在插入后接触返回潜伏期、退出潜伏期和撤退持续时间，以及在交配、插入和射精后的退出潜伏期后观察到的潜伏期较短。
在 30 分钟配种测试中，插入后接触返回潜伏期和射精后退出潜伏期较长，这最好归因于女性的 PEI。PEI 的持续时间是影响配种行为的特定因素。
从这些模型中学习到的影响性行为的神经生物学机制和感觉因素的理解可以应用于人类女性性健康的研究。
性行为的动机是通过类似的行为来表示，并得到了女性和大鼠中进化保守系统的支持，这意味着可以使用动物模型来确定这些行为的神经生物学机制。尽管如此，未来的研究仍需要有关不同交配范式的生理影响的具体数据。
模仿自然环境的程序，从而使女性性动机驱动行为，适合用于研究支持女性性功能的机制，而人为地延长射精和随后插入之间的间隔可能提供一种研究女性性功能障碍的模型。
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