Suppr超能文献

rs1042522 C>G 多态性与中国儿童脑肿瘤风险的关联。

Association of rs1042522 C>G Polymorphism with Glioma Risk in Chinese Children.

机构信息

School of Medicine, South China University of Technology, Guangzhou, 510006 Guangdong, China.

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623 Guangdong, China.

出版信息

Biomed Res Int. 2022 Aug 13;2022:2712808. doi: 10.1155/2022/2712808. eCollection 2022.

Abstract

Glioma is the most common intracranial malignancy. is a crucial tumor suppressor gene that plays an essential regulatory role in cell growth, apoptosis, and DNA repair. The rs1042522 C>G polymorphism has been reported to be strongly associated with various tumor risks. To assess the rs1042522 C>G polymorphism with glioma risk in Chinese children, we determined the genotypes of the rs1042522 C>G polymorphism in 171 glioma patients and 228 cancer-free controls by Taqman assay. We assessed the association of the polymorphism with glioma risk using odds ratio (OR) and 95% confidence interval (CI) generated by logistic regression models. We also performed stratified analyses by age, gender, tumor subtypes, and clinical stages, but no significant association was detected between rs1042522 C>G polymorphism and childhood glioma risk. These results suggest that the rs1042522 C>G polymorphism is not associated with glioma risk in Chinese children. Subsequent studies with a larger sample size are needed to validate our results.

摘要

神经胶质瘤是最常见的颅内恶性肿瘤。 CDKN2A 是一种重要的肿瘤抑制基因,在细胞生长、凋亡和 DNA 修复中发挥着重要的调节作用。 rs1042522 C>G 多态性与多种肿瘤风险密切相关。为了评估 CDKN2A 基因 rs1042522 C>G 多态性与中国儿童神经胶质瘤发病风险的关系,我们采用 Taqman 法检测了 171 例神经胶质瘤患者和 228 例无癌对照者 rs1042522 C>G 多态性的基因型。采用 logistic 回归模型计算比值比(OR)及其 95%置信区间(CI)来评估该多态性与神经胶质瘤发病风险的关系。我们还按年龄、性别、肿瘤亚型和临床分期进行了分层分析,但未发现 rs1042522 C>G 多态性与儿童神经胶质瘤发病风险之间存在显著相关性。这些结果提示 CDKN2A 基因 rs1042522 C>G 多态性与中国儿童神经胶质瘤发病风险无关。需要更大样本量的后续研究来验证我们的结果。

相似文献

1
Association of rs1042522 C>G Polymorphism with Glioma Risk in Chinese Children.
Biomed Res Int. 2022 Aug 13;2022:2712808. doi: 10.1155/2022/2712808. eCollection 2022.
2
rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case-control study.
Biosci Rep. 2019 Jan 22;39(1). doi: 10.1042/BSR20181891. Print 2019 Jan 31.
3
The gene rs1042522 C>G polymorphism and neuroblastoma risk in Chinese children.
Aging (Albany NY). 2017 Mar 8;9(3):852-859. doi: 10.18632/aging.101196.
5
Association of the rs1042522 C>G polymorphism and hepatoblastoma risk in Chinese children.
J Cancer. 2019 Jun 9;10(15):3444-3449. doi: 10.7150/jca.33063. eCollection 2019.
6
Association between TP53 rs1042522 gene polymorphism and the risk of malignant bone tumors: a meta-analysis.
Biosci Rep. 2019 Mar 19;39(3). doi: 10.1042/BSR20181832. Print 2019 Mar 29.
9
Association of TP53 rs1042522 with cervical cancer in the sub-Saharan African population: a meta-analysis.
Trop Med Int Health. 2020 Jun;25(6):666-672. doi: 10.1111/tmi.13397. Epub 2020 Apr 16.
10
The functional TP53 rs1042522 and MDM4 rs4245739 genetic variants contribute to Non-Hodgkin lymphoma risk.
PLoS One. 2014 Sep 9;9(9):e107047. doi: 10.1371/journal.pone.0107047. eCollection 2014.

引用本文的文献

1
Gene 72 Arg/Pro (rs1042522) single nucleotide polymorphism increases the risk and the severity of chronic lymphocytic leukemia.
Front Oncol. 2023 Oct 16;13:1272876. doi: 10.3389/fonc.2023.1272876. eCollection 2023.
2
Association between GPC2 polymorphisms and neuroblastoma risk in Chinese children.
J Clin Lab Anal. 2023 Mar;37(5):e24866. doi: 10.1002/jcla.24866. Epub 2023 Mar 15.

本文引用的文献

2
Role of and gene polymorphisms in susceptibility to pediatric acute lymphoblastic leukemia.
Oncol Lett. 2021 Sep;22(3):659. doi: 10.3892/ol.2021.12920. Epub 2021 Jul 13.
4
Genetic variants in mA modification core genes are associated with glioma risk in Chinese children.
Mol Ther Oncolytics. 2021 Jan 5;20:199-208. doi: 10.1016/j.omto.2020.12.013. eCollection 2021 Mar 26.
6
Cancer statistics, 2020.
CA Cancer J Clin. 2020 Jan;70(1):7-30. doi: 10.3322/caac.21590. Epub 2020 Jan 8.
7
Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis.
Int J Mol Sci. 2019 Dec 8;20(24):6197. doi: 10.3390/ijms20246197.
8
Association of miR-34b/c rs4938723 and TP53 Arg72Pro Polymorphisms with Neuroblastoma Susceptibility: Evidence from Seven Centers.
Transl Oncol. 2019 Oct;12(10):1282-1288. doi: 10.1016/j.tranon.2019.06.008. Epub 2019 Jul 17.
9
gene rs1042522 allele G decreases neuroblastoma risk: a two-centre case-control study.
J Cancer. 2019 Jan 1;10(2):467-471. doi: 10.7150/jca.27482. eCollection 2019.
10
Association Between Genetic Variant in the Promoter of Pri-miR-34b/c and Risk of Glioma.
Front Oncol. 2018 Sep 26;8:413. doi: 10.3389/fonc.2018.00413. eCollection 2018.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验