可溶性尿体细胞血管紧张素转换酶在子痫前期患者中过度表达：一种疾病的潜在新标志物？
Soluble urinary somatic angiotensin converting enzyme is overexpressed in patients with preeclampsia: a potential new marker for the disease?
机构信息
Division of Nephrology & Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Postgraduate Program in Medicine and Health Sciences, Pontifical Catholic University of Rio Grande Do Sul, Porto Alegre, Brazil.
出版信息
Hypertens Pregnancy. 2022 Aug-Nov;41(3-4):190-197. doi: 10.1080/10641955.2022.2115060. Epub 2022 Aug 23.
Abstract
OBJECTIVE
The aim of this study was to identify and quantify urinary Angiotensin-Converting-Enzyme (ACE) in hypertensive disorders of pregnancy.
METHODS
Urine samples were analyzed by Western blot. Patients were classified into: normotensive pregnancy (N); preeclampsia and superimposed preeclampsia (PE+SPE); and gestational hypertension (GH).
RESULTS
Somatic ACE protein expression was higher in PE+SPE compared to N and GH. There was a positive correlation between ACE and urinary protein to creatinine ratio, systolic and diastolic blood pressures.
CONCLUSION
These results indicate ACE overexpression in the urine of preeclamptic patients and suggest that it may be a new marker for the disease.
摘要
目的
本研究旨在鉴定和定量妊娠高血压疾病患者尿液中的血管紧张素转换酶（ACE）。
方法
采用 Western blot 分析尿液样本。患者分为：正常妊娠（N）；子痫前期和重叠子痫前期（PE+SPE）；和妊娠期高血压（GH）。
结果
PE+SPE 患者尿液中 ACE 蛋白表达高于 N 和 GH。ACE 与尿蛋白与肌酐比值、收缩压和舒张压呈正相关。
结论
这些结果表明子痫前期患者尿液中 ACE 过度表达，并提示其可能是该疾病的新标志物。
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