卷曲蛋白（Frizzled）不受 Wnt 影响。
Frizzled does not get bent out of shape by Wnt.
机构信息
Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.
Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
出版信息
Sci Signal. 2022 Aug 23;15(748):eadd3535. doi: 10.1126/scisignal.add3535.
Ligands of the Wnt family activate the Frizzled-LRP5/6 receptor complex to initiate intracellular signaling. In this issue of , Mahoney reveal a Wnt-stimulated positive feedback loop that involves local production of the lipid phosphatidylinositol(4,5)bisphosphate [PI(4,5)P], which promotes Dishevelled recruitment and additional PI(4,5)P production, to facilitate LRP5/6 phosphorylation.
Wnt 家族的配体激活卷曲蛋白-LRP5/6 受体复合物，从而启动细胞内信号转导。在本期杂志中，Mahoney 揭示了一个 Wnt 刺激的正反馈回路，涉及脂质磷脂酰肌醇（4,5）二磷酸 [PI（4,5）P] 的局部产生，该脂质促进 Dishevelled 的募集和更多的 PI（4,5）P 的产生，从而促进 LRP5/6 的磷酸化。
Zotero 插件