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标准化肝体积和体重指数与微创肝切除术结果的关联。

Association of standardized liver volume and body mass index with outcomes of minimally invasive liver resections.

机构信息

Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital and National Cancer Centre Singapore, Academia, Level 5, 20 College Road, Singapore, 169856, Singapore.

Duke-National University of Singapore Medical School, Singapore, Singapore.

出版信息

Surg Endosc. 2023 Jan;37(1):456-465. doi: 10.1007/s00464-022-09534-x. Epub 2022 Aug 23.

Abstract

INTRODUCTION

While minimally invasive liver resections (MILR) have demonstrated advantages in improved post-operative recovery, widespread adoption is hampered by inherent technical difficulties. Our study attempts to analyze the role of anthropometric measures in MILR-related outcomes.

METHODS

Between 2012 and 2020, 676 consecutive patients underwent MILR at the Singapore General Hospital of which 565 met study criteria and were included. Patients were stratified based on Body Mass Index (BMI) as well as Standardized Liver Volumes (SLV). Associations between BMI and SLV to selected peri-operative outcomes were analyzed using restricted cubic splines.

RESULTS

A BMI of ≥ 29 was associated with increase in blood loss [Mean difference (MD) 69 mls, 95% CI 2 to 137] as well as operative conversions [Relative Risk (RR) 1.63, 95% CI 1.02 to 2.62] among patients undergoing MILR while a SLV of 1600 cc or higher was associated with an increase in blood loss (MD 30 mls, 95% CI 10 to 49). In addition, a BMI of ≤ 20 was associated with an increased risk of major complications (RR 2.25, 95% 1.16 to 4.35). The magnitude of differences observed in these findings increased with each unit change in BMI and SLV.

CONCLUSION

Both BMI and SLV were useful anthropometric measures in predicting peri-operative outcomes in MILR and may be considered for incorporation in future difficulty scoring systems for MILR.

摘要

简介

虽然微创肝切除术(MILR)在改善术后恢复方面具有优势,但由于其固有的技术难度,其广泛应用受到阻碍。我们的研究试图分析人体测量指标在 MILR 相关结果中的作用。

方法

在 2012 年至 2020 年间,新加坡总医院有 676 例连续患者接受了 MILR,其中 565 例符合研究标准并被纳入研究。根据体重指数(BMI)和标准肝体积(SLV)对患者进行分层。使用限制立方样条分析 BMI 和 SLV 与选定围手术期结果之间的关联。

结果

BMI≥29 与 MILR 患者的出血量增加相关[平均差值(MD)69ml,95%置信区间(CI)2 至 137],以及手术转换率增加相关[相对风险(RR)1.63,95%CI 1.02 至 2.62],而 SLV 为 1600cc 或更高与出血量增加相关(MD 30ml,95%CI 10 至 49)。此外,BMI≤20 与主要并发症的风险增加相关(RR 2.25,95%CI 1.16 至 4.35)。这些发现中的差异幅度随着 BMI 和 SLV 的每个单位变化而增加。

结论

BMI 和 SLV 都是预测 MILR 围手术期结果的有用人体测量指标,可考虑纳入未来的 MILR 困难评分系统。

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