Ashok Kumar Prashanth, Wang Dongliang, Huang Danning, Paulraj Shweta, Sivapiragasam Abirami
Hematology-Oncology, Upstate University Hospital, Syracuse, USA.
Public Health and Preventive Medicine, Upstate University Hospital, Syracuse, USA.
Cureus. 2022 Jul 21;14(7):e27109. doi: 10.7759/cureus.27109. eCollection 2022 Jul.
Lacrimal gland tumors are rare with data limited to very few large studies. Contemporary strategies like orbit sparing surgeries and neoadjuvant intraarterial chemotherapy remain controversial.
This is a retrospective cohort analysis of epithelial lacrimal gland tumors from the 2004-2016 National Cancer Database. Patients were stratified based on the type of surgery (limited vs destructive) and various treatment modalities employed.
Squamous cell carcinoma (33.48%) and adenoid cystic carcinoma (29.45%) were the commonest histologies (N=669). Comparison of limited (46.33%) vs destructive procedures (53.11%) among 482 patients did not show any survival difference, nor the comparison between surgery vs ± chemotherapy vs ± radiotherapy among 472 patients.
Squamous cell carcinoma and adenoid cystic carcinoma are the commonest types of lacrimal gland tumors seen in our study. Tumor spread from adjacent sites may have contributed to the higher percentage of squamous cell carcinomas seen. The type of surgery or chemoradiation use did not alter survival.
泪腺肿瘤较为罕见，相关数据仅限于极少数大型研究。诸如保眶手术和新辅助动脉内化疗等现代策略仍存在争议。
这是一项对2004年至2016年国家癌症数据库中上皮性泪腺肿瘤的回顾性队列分析。患者根据手术类型（局限性手术与破坏性手术）以及所采用的各种治疗方式进行分层。
鳞状细胞癌（33.48%）和腺样囊性癌（29.45%）是最常见的组织学类型（n = 669）。482例患者中，局限性手术（46.33%）与破坏性手术（53.11%）的比较未显示出生存差异，472例患者中手术与±化疗与±放疗之间的比较也未显示出生存差异。
鳞状细胞癌和腺样囊性癌是我们研究中最常见的泪腺肿瘤类型。肿瘤从相邻部位扩散可能是鳞状细胞癌比例较高的原因。手术类型或放化疗的使用并未改变生存率。
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