Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
J Cancer Res Clin Oncol. 2024 Jan 23;150(1):26. doi: 10.1007/s00432-023-05510-7.
The incidence of lacrimal gland adenocarcinoma is low. This study was designed to analyze the clinical and prognostic characteristics of lacrimal gland adenocarcinoma.
This was a clinical study and literature review; 25 patients diagnosed with lacrimal gland adenocarcinoma by histopathology were enrolled and their medical history data were collected.
The incidence of bone destruction and surrounding tissue invasion was 52% and 44%, respectively. The incidence of distant metastasis of lacrimal gland adenocarcinoma was about 50%. The 5-year overall survival rate of death or metastasis was 33.5%. Age, sex, laterality, tumor size, pathology type, bone destruction, nerve or perineural invasion, invasion of peripheral tissue, T stage, AR, Her-2 and treatment had no significant correlation with lacrimal adenocarcinoma's prognosis (P > 0.05), while the higher expression of Ki-67 may have higher risk of death or metastasis (P = 0.020).
The incidence of bone destruction and distant metastasis of lacrimal adenocarcinoma is high and the imaging examination is necessary to assess the risk of distant metastasis. The 5-year survival rate of death or metastasis is 33.5% and the high expression of Ki-67 predicts poor prognosis of lacrimal adenocarcinoma.
泪腺癌的发病率较低。本研究旨在分析泪腺癌的临床和预后特征。
这是一项临床研究和文献回顾；共纳入 25 例经组织病理学诊断为泪腺癌的患者，并收集了他们的病史资料。
骨破坏和周围组织侵犯的发生率分别为 52%和 44%。泪腺癌远处转移的发生率约为 50%。死亡或转移的 5 年总生存率为 33.5%。年龄、性别、侧别、肿瘤大小、病理类型、骨破坏、神经或神经周围侵犯、周围组织侵犯、T 分期、AR、Her-2 和治疗与泪腺癌的预后无显著相关性（P＞0.05），而 Ki-67 的高表达可能有更高的死亡或转移风险（P=0.020）。
泪腺癌骨破坏和远处转移的发生率较高，需要进行影像学检查以评估远处转移的风险。死亡或转移的 5 年生存率为 33.5%，Ki-67 的高表达预示着泪腺癌预后不良。
