Division of Nephrology and Endocrinology, The Chonggang General Hospital Affiliated to Chongqing University of Posts and Telecommunications, Chongqing, People's Republic of China.
Department of Emergency and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Ren Fail. 2022 Dec;44(1):1409-1416. doi: 10.1080/0886022X.2022.2114369.
Vascular calcification (VC) and secondary hyperparathyroidism (SHPT) are important causes of the high incidence of cardiovascular events in chronic kidney disease (CKD) patients. The relationship between parathyroid hormone (PTH) and VC is very complex. The aim of this study was to determine the correlation between PTH levels and abdominal aortic calcification (AAC) in patients starting hemodialysis who had not received calcium tablets, calcium-containing phosphorus binders, calcitriol, or vitamin D analogs.
Seventy-one patients were included. Latero-lateral X-ray lumbar radiography, serum intact PTH (iPTH) levels, and predialysis biochemical parameters were obtained. The degree of AAC was evaluated according to the methods described previously by Kauppila et al.
We found that there was a strong negative correlation between serum PTH and AAC (Spearman's rho -0.76, < 0.001). Receiver operating characteristic (ROC) curve analysis showed that low serum PTH level could predict the presence and extent of AAC (area under the curve values were 0.9013 [ < 0.0001] and 0.780 [ = 0.0041], respectively).
Our results indicate that serum PTH level is significantly negatively correlated with AAC within a certain concentration range in patients starting hemodialysis who had not received calcium tablets, calcium-containing phosphorus binders, calcitriol, or vitamin D analogs.
血管钙化（VC）和继发性甲状旁腺功能亢进症（SHPT）是慢性肾脏病（CKD）患者心血管事件高发的重要原因。甲状旁腺激素（PTH）与 VC 之间的关系非常复杂。本研究旨在确定未接受钙剂、含钙磷结合剂、骨化三醇或维生素 D 类似物治疗的开始血液透析患者的 PTH 水平与腹主动脉钙化（AAC）之间的相关性。
共纳入 71 例患者。获取侧位腰椎 X 线片、血清全段甲状旁腺激素（iPTH）水平和透析前生化参数。根据 Kauppila 等人先前描述的方法评估 AAC 程度。
我们发现血清 PTH 与 AAC 之间存在强烈的负相关关系（Spearman's rho -0.76，<0.001）。受试者工作特征（ROC）曲线分析显示，低血清 PTH 水平可预测 AAC 的存在和程度（曲线下面积值分别为 0.9013 [<0.0001] 和 0.780 [=0.0041]）。
我们的研究结果表明，在未接受钙剂、含钙磷结合剂、骨化三醇或维生素 D 类似物治疗的开始血液透析患者中，血清 PTH 水平在一定浓度范围内与 AAC 显著负相关。
