早期去势抵抗性前列腺癌中 F-FACBC 的正电子发射断层扫描/计算机断层扫描：我们的初步结果。

Digital PET/CT with F-FACBC in early castration-resistant prostate cancer: our preliminary results.

机构信息

Department of Nuclear Medicine, Santa Maria Goretti Hospital, Latina, Italy.

Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.

出版信息

Expert Rev Med Devices. 2022 Jul;19(7):591-598. doi: 10.1080/17434440.2022.2117612. Epub 2022 Aug 28.

DOI:10.1080/17434440.2022.2117612

PMID:36001041

Abstract

BACKGROUND

We assessed the role of digital PET/CT (dPET/CT) with F-FACBC in patients affected by castration-resistant prostate cancer with PSA levels ≤ 3 ng/mL (early CRPC), no lesions detectable at cross-sectional imaging (CIM) and bone scan (BS).

METHODS

Clinical data of patients submitted to F-FACBC dPET/CT were retrospectively reviewed. PET/CT results were analyzed: lesions' number, location, and, in case of positive lymph nodes, largest node's short axis (i.e. SA) were annotated. According to PET/CT's results, patients with F-FACBC-avid lesions were further stratified into 1) unifocal; 2) oligometastatic (≤ 5 lesions); 3) disseminated (> 6 lesions).

RESULTS

Twenty-four patients were enrolled. F-FACBC dPET/CT was positive in 21 out of 24 patients (87.5%). Thirteen patients (54.1%) showed recurrence in pelvic region, seven of whom with pelvic nodes' involvement, while eight cases (33.3%) presented F-FACBC-avid metastases to extra-pelvic nodes or bone. Average SA of PET-positive nodes resulted in 8.9 ± 3 mm. Patients were categorized as unifocal in four cases (26.6%), oligometastatic in 10 subjects (66.6%) and disseminated in 1 case (0.6%). PET/CT impacted on clinical management in 14 cases (58.3%).

CONCLUSIONS

F-FACBC dPET/CT detected M1 status in 33.3% of early CRPC patients, significantly impacting on clinical management.

摘要

背景

我们评估了 F-FACBC 标记的数字正电子发射断层扫描/计算机断层扫描（dPET/CT）在前列腺特异性抗原（PSA）水平≤3ng/ml（早期去势抵抗性前列腺癌，CRPC）、横断面成像（CIM）和骨扫描（BS）无可检测病灶的患者中的作用。

方法

回顾性分析了接受 F-FACBC dPET/CT 的患者的临床数据。分析了 PET/CT 结果：记录病灶数量、位置，以及在阳性淋巴结的情况下，记录最大淋巴结短轴（即短轴）。根据 PET/CT 结果，将 F-FACBC 阳性的患者进一步分为 1）单灶；2）寡转移（≤5 个病灶）；3）广泛转移（>6 个病灶）。

结果

共纳入 24 例患者。24 例患者中，21 例（87.5%）F-FACBC dPET/CT 阳性。13 例（54.1%）患者出现盆腔区域复发，其中 7 例伴有盆腔淋巴结受累，8 例（33.3%）出现骨盆外淋巴结或骨骼的 F-FACBC 阳性转移。阳性淋巴结的平均短轴为 8.9±3mm。4 例（26.6%）患者为单灶，10 例（66.6%）患者为寡转移，1 例（0.6%）患者为广泛转移。14 例（58.3%）患者的 PET/CT 影响了临床管理。