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单次社会挫败暴露是否会使大鼠比短暂不可逃避的足底电击更容易发生化学诱导的结肠炎?

Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks?

机构信息

Regional Centre for Child and Youth Mental Health and Child Welfare, Norwegian Research Centre, NORCE, Bergen, Norway.

Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.

出版信息

PLoS One. 2022 Aug 24;17(8):e0263802. doi: 10.1371/journal.pone.0263802. eCollection 2022.

Abstract

All mammals are to different degrees exposed to stressors being physical or social, which may affect health and well-being. Stressful and traumatic situations have direct effects on immune responses that may alter susceptibility to developing somatic illnesses. In animal research, different types of stressors have been investigated in studying the effect on bowel disorders, some stressors being more or less of environmental origin. We aimed, therefore, to explore whether a more natural stressor would differ from a stressor of more unnatural characteristics on dextran sulphate sodium (DSS) induced colitis in adult rats. Specifically, whether social stress within a single social defeat (SD) paradigm would be a more potent stressor than brief inescapable foot-shocks (IFS) in causing elevated faecal granulocyte marker protein (GMP), and crypt- and inflammation scores in colonic tissue. Three groups of male Wistar rats were used; socially defeated rats; inescapable foot-shock rats; and comparison rats. Main findings showed no difference between the groups on GMP levels. However, there was a significant difference on inflammation and crypt scores for the distal part of colon, detected through histology, where socially defeated rats were more susceptible. A single SD seems to be more adverse than inescapable foot-shock on DSS induced colitis, but further studies are recommended to validate a broader range of different outcomes comparing two such different rodent stress models.

摘要

所有哺乳动物在不同程度上都受到生理或社会压力源的影响,这可能会影响健康和幸福感。压力和创伤性情况会直接影响免疫反应,从而改变患上躯体疾病的易感性。在动物研究中,已经研究了不同类型的压力源对肠道疾病的影响,其中一些压力源或多或少具有环境来源。因此,我们旨在探索一种更自然的压力源是否会与一种更不自然的压力源在成年大鼠的葡聚糖硫酸钠(DSS)诱导的结肠炎上产生不同的影响。具体来说,在引起粪便嗜中性粒细胞标志物蛋白(GMP)和结肠组织隐窝和炎症评分升高方面,单一社交挫败(SD)范式内的社交压力是否会比短暂的不可逃避的足部电击(IFS)更有效。使用了三组雄性 Wistar 大鼠;社交挫败大鼠;不可逃避的足部电击大鼠;和对照组大鼠。主要发现表明,各组之间的 GMP 水平没有差异。然而,通过组织学检测到,在远端结肠的炎症和隐窝评分上存在显著差异,社交挫败大鼠更容易受到影响。单次 SD 似乎比不可逃避的足部电击对 DSS 诱导的结肠炎更不利,但需要进一步研究来验证两种不同的啮齿动物应激模型之间更广泛的不同结果的比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213d/9401109/6b89cf0bffeb/pone.0263802.g001.jpg

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