Ueno S, Matsuki N, Saito H
Life Sci. 1987 Jul 27;41(4):513-8. doi: 10.1016/0024-3205(87)90229-3.
Effects of various emetic and antiemetic drugs were studied using Suncus murinus for its potential use as an experimental model in emetic research. Subcutaneous injection of nicotine bitartrate (10-15 mg/kg), veratrine sulfate (0.5-1.0 mg/kg), emetine dihydrochloride (40-80 mg/kg) and oral administration of copper sulfate (20-100 mg/kg) caused dose-dependent emesis in suncus. The ED50 of nicotine, veratrine, emetine and copper sulfate were 7.9, 0.4, 47.6 and 21.4 mg/kg, respectively. However, subcutaneously injected apomorphine hydrochloride (0.1-100 mg/kg), digitoxin (0.5-1.0 mg/kg) and orally administered emetine dihydrochloride (10-80 mg/kg) did not induce the vomiting. Chlorpromazine and promethazine decreased the emetic effect of nicotine, veratrine and copper sulfate, but scopolamine hydrobromide was not effective. These results indicate that the Suncus murinus is sensitive to various emetic and antiemetic drugs and can be used as a new experimental animal model for the emesis. Emetic behavior of suncus was discussed in comparison with other animals.
研究了各种催吐药和止吐药对麝鼩的作用，以探讨其作为催吐研究实验模型的潜在用途。皮下注射重酒石酸尼古丁（10 - 15毫克/千克）、硫酸藜芦碱（0.5 - 1.0毫克/千克）、盐酸依米丁（40 - 80毫克/千克）以及口服硫酸铜（20 - 100毫克/千克）可使麝鼩产生剂量依赖性呕吐。尼古丁、藜芦碱、依米丁和硫酸铜的半数有效量（ED50）分别为7.9、0.4、47.6和21.4毫克/千克。然而，皮下注射盐酸阿扑吗啡（0.1 - 100毫克/千克）、洋地黄毒苷（0.5 - 1.0毫克/千克）以及口服盐酸依米丁（10 - 80毫克/千克）未引发呕吐。氯丙嗪和异丙嗪可降低尼古丁、藜芦碱和硫酸铜的催吐作用，但氢溴酸东莨菪碱无效。这些结果表明，麝鼩对各种催吐药和止吐药敏感，可作为一种新的呕吐实验动物模型。并将麝鼩的呕吐行为与其他动物进行了比较。
