Department of Pathophysiology, Medical College of Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Department of Pathophysiology, Medical College of Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Eur J Pharmacol. 2022 Sep 15;931:175229. doi: 10.1016/j.ejphar.2022.175229. Epub 2022 Aug 21.
Tumour-associated macrophages (TAMs) have been found to be of great importance in tumorigenesis and in promoting malignant progression, including tumour angiogenesis and metastasis. Moreover, the TAM phenotype is more likely to be an M2 type. Transforming TAMs by M2-polarization into the tumour-suppressive M1-phenotype is an important approach for tumour therapy. In this review, we analysed the effects of the tumour microenvironment on macrophage phenotype-switching, including hypoxia and cytokines, and the mechanisms of drugs targeting TAMs. Furthermore, we analysed the effects of exosomes on macrophage polarization, phenotype switching of macrophages, and the mechanisms of lipid mediators targeting TAMs.
肿瘤相关巨噬细胞（TAMs）在肿瘤发生和促进恶性进展方面具有重要作用，包括肿瘤血管生成和转移。此外，TAM 表型更可能是 M2 型。通过将 TAMs 从 M2 极化转化为肿瘤抑制性 M1 表型是肿瘤治疗的重要方法。在这篇综述中，我们分析了肿瘤微环境对巨噬细胞表型转换的影响，包括缺氧和细胞因子，以及针对 TAMs 的药物的作用机制。此外，我们还分析了外泌体对巨噬细胞极化、巨噬细胞表型转换的影响，以及针对 TAMs 的脂质介质的作用机制。
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