N(6)-methyladenosine modification: A vital role of programmed cell death in myocardial ischemia/reperfusion injury.

N(6)-methyladenosine (mA) modification is closely associated with myocardial ischemia/reperfusion injury (MIRI). As the most common modification among RNA modifications, the reversible mA modification is processed by methylase ("writers") and demethylase ("erasers"). The biological effects of RNA modified by mA are regulated under the corresponding RNA binding proteins (RBPs) ("readers"). mA modification regulates the whole process of RNA, including transcription, processing, splicing, nuclear export, stability, degradation, and translation. Programmed cell death (PCD) is a regulated mechanism that maintains the internal environment's stability. PCD plays an essential role in MIRI, including apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis. However, the relationship between PCD modified with mA and MIRI is still not clear. This review summarizes the regulators of mA modification and their bioeffects on PCD in MIRI.