在胰腺自由呼吸动态对比增强磁共振成像中达到良好图像质量和进行药代动力学分析的最佳时间分辨率。
Optimal Temporal Resolution to Achieve Good Image Quality and Perform Pharmacokinetic Analysis in Free-breathing Dynamic Contrast-enhanced MR Imaging of the Pancreas.
机构信息
Department of Radiology, Shinshu University School of Medicine.
Radiology Division, Shinshu University Hospital.
出版信息
Magn Reson Med Sci. 2023 Oct 1;22(4):477-485. doi: 10.2463/mrms.mp.2022-0035. Epub 2022 Aug 23.
PURPOSE
The optimal temporal resolution for free-breathing dynamic contrast-enhanced MRI (FBDCE-MRI) of the pancreas has not been determined. This study aimed to evaluate the appropriate temporal resolution to achieve good image quality and to perform pharmacokinetic analysis in FBDCE-MRI of the pancreas using golden-angle radial sparse parallel (GRASP).
METHODS
Sixteen participants (53 ± 15 years, eight females) undergoing FBDCE-MRI were included in this prospective study. Images were retrospectively reconstructed at four temporal resolutions (1.8, 3.0, 4.8, and 7.8s). Two radiologists (5 years of experience) evaluated the image quality of each reconstructed image by assessing the visualization of the celiac artery (CEA), the common hepatic artery, the splenic artery, each area of the pancreas, and artifacts using a 5-point scale. Using Tissue-4D, pharmacokinetic parameters were calculated for each area in the reconstructed images at each temporal resolution for 16 examinations, excluding two with errors in the pharmacokinetic modeling analysis. Friedman and Bonferroni tests were used for analysis. A P value < 0.05 was considered statistically significant.
RESULTS
During vascular assessment, only scores for the CEA at 7.8s were significantly lower than the other temporal resolutions. Scores of all pancreatic regions and artifacts were significantly lower at 1.8s than at 4.8s and 7.8s. In the pharmacokinetic analysis, all volume transfer coefficients (K), rate constants (K), and the initial area under the concentration curve (iAUC) in the pancreatic head and tail were significantly lower at 4.8s and 7.8s than at 1.8s. iAUC in the pancreatic body and extracellular extravascular volume fraction (V) in the pancreatic head were significantly lower at 7.8s than at 1.8s.
CONCLUSION
A temporal resolution of 3.0s is appropriate to achieve image quality and perform pharmacokinetic analysis in FBDCE-MRI of the pancreas using GRASP.
目的
尚未确定自由呼吸动态对比增强磁共振成像（FBDCE-MRI）胰腺检查的最佳时间分辨率。本研究旨在使用黄金角度放射状稀疏并行采集（GRASP）技术评估合适的时间分辨率，以获得良好的胰腺 FBDCE-MRI 图像质量并进行药代动力学分析。
方法
本前瞻性研究纳入了 16 名参与者（53±15 岁，8 名女性）行 FBDCE-MRI 检查。将图像以 4 种时间分辨率（1.8、3.0、4.8 和 7.8s）进行回顾性重建。两位放射科医生（具有 5 年经验）使用 5 分制评估了每个重建图像的图像质量，评估内容包括腹腔动脉（CEA）、肝总动脉、脾动脉、胰腺各区域和伪影的可视化程度。使用 Tissue-4D，在每个时间分辨率下对 16 次检查中每个重建图像的各个区域计算药代动力学参数，两次药代动力学建模分析出现错误的检查除外。采用 Friedman 和 Bonferroni 检验进行分析。P 值＜0.05 被认为具有统计学意义。
结果
在血管评估中，仅 7.8s 时的 CEA 评分明显低于其他时间分辨率。所有胰腺区域和伪影的评分在 1.8s 时均明显低于 4.8s 和 7.8s。在药代动力学分析中，胰头部和尾部的所有容积转移系数（K）、速率常数（K）和初始浓度曲线下面积（iAUC）在 4.8s 和 7.8s 时明显低于 1.8s。胰体部的 iAUC 和胰头部的细胞外细胞外容积分数（V）在 7.8s 时明显低于 1.8s。
结论
使用 GRASP 进行胰腺 FBDCE-MRI 检查时，3.0s 的时间分辨率适合获得图像质量并进行药代动力学分析。
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