Alsulaiman Abdullah S, Alharthi Siraj B, Albariqi Ahmed S, Mutabaqani Rasha A, Bokhari Fawzi F, Tayeb Islam M, Alharthi Dalia R, Tariq Muhammad U, Babaier Yasser H
Molecular Diagnostic Unit, Alhada Armed Forces Hospital, Taif, SAU.
Biological Sciences, King Abdulaziz University, Jeddah, SAU.
Cureus. 2022 Jul 21;14(7):e27090. doi: 10.7759/cureus.27090. eCollection 2022 Jul.
We report the first documented case series of two lung adenocarcinoma patients demonstrating Kirsten rat sarcoma viral oncogene homolog (KRAS) G12C mutations by reverse transcription-polymerase chain reaction techniques from Saudi Arabia. Both patients were males aged 64 and 76 years. The first had a heavy smoking history, while the second did not report any history of smoking. The tumor subtype was identified to be non-mucinous lung adenocarcinoma in both cases. The younger patient presented with generalized lymphadenopathy and a right-sided lung mass lesion, while the older patient exhibited stage III-A left lung adenocarcinoma that required rapid response. An initial examination of the first case showed a right-sided mediastinal shift, bilateral neck lymphadenopathy, and poorly differentiated neoplasm from a right supraclavicular core biopsy, leading to treatment with palliatives along with regular checkups. The second case was afebrile after being confirmed to be vitally stable and laboratory testing (Neutr 100). Further studies, specifically on large numbers of patients from the Arabian Gulf, are needed to confirm significant differences between the national and international populations. Additionally, future studies should investigate more differences in the differentiation of KRAS-mutant lung adenocarcinoma between patients from the Arabian Gulf and others.
我们报告了沙特阿拉伯首例通过逆转录-聚合酶链反应技术证实存在 Kirsten 大鼠肉瘤病毒癌基因同源物（KRAS）G12C 突变的两例肺腺癌患者的病例系列。两名患者均为男性，年龄分别为 64 岁和 76 岁。第一名患者有重度吸烟史，而第二名患者未报告任何吸烟史。两例患者的肿瘤亚型均被确定为非黏液性肺腺癌。较年轻的患者表现为全身淋巴结肿大和右侧肺部肿块病变，而较年长的患者表现为 III - A 期左肺腺癌，需要快速治疗。对第一例病例的初步检查显示右侧纵隔移位、双侧颈部淋巴结肿大，以及右锁骨上核心活检的低分化肿瘤，导致采用姑息治疗并定期检查。第二例病例在确认生命体征稳定且实验室检查（中性粒细胞 100）后无发热症状。需要进一步开展研究，特别是针对大量来自阿拉伯湾地区的患者，以确认本国人群与国际人群之间的显著差异。此外，未来的研究应调查阿拉伯湾地区患者与其他患者之间 KRAS 突变型肺腺癌分化方面的更多差异。
