Chen Danyan, Meng Ziyan, Zhao Tingting, Yu Xueqian, He Hong, Hua Fang, Dong Weili
Hubei-MOST KLOS and KLOBM, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Department of Periodontology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Front Med (Lausanne). 2022 Aug 8;9:960245. doi: 10.3389/fmed.2022.960245. eCollection 2022.
Sleep-disordered breathing (SDB) is a chronic sleep-related breathing disorder, considered associated with increased risk of cardiovascular disorders, metabolic disorders, cognitive dysfunction and behavior changes. Periodontal diseases are chronic infectious diseases that are also believed to be associated with cardiovascular diseases, metabolic syndrome and cognitive dysfunction. Several studies have indicated that SDB may be associated with periodontal diseases through certain mechanisms such as inflammation response, oxidative stress and oral dryness. The aim of this systematic review is to explore the association between SDB and periodontal diseases in an integrated approach.
This systematic review will include cohort studies, cross-sectional studies and case-control studies that are identified by electronic and manual searches. Electronic searches will be conducted in the following databases: PubMed, Embase, Scopus and Web of Science. Our search will cover articles published from inception of databases to March 2022 without restrictions in language and settings. Pre-determined eligibility criteria include: participants (participants without a history of respiratory diseases, history of periodontal treatment within the past 6 months and history of medication that is known to influence SDB or periodontal diseases); exposure (participants who have been diagnosed with SDB or at high-risk for SDB); comparison (participants without SDB); and outcome (periodontal parameters, such as probing depth, clinical attachment level, bleeding on probing, radiographic bone loss). Two authors will perform study screening and data extraction independently and in duplicate. All discrepancies will be solved by discussion. The methodological quality of included studies will be assessed using the Newcastle-Ottawa Scale.
This systematic review will summarize the existing evidence on the association between SDB and periodontal diseases, a topic of controversy and clinical significance. Its findings can provide evidence for the development of relevant prevention and treatment strategies. The results will be disseminated through peer-reviewed journals.
https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022313024. Registered on March 28th 2022.
睡眠呼吸障碍（SDB）是一种与睡眠相关的慢性呼吸障碍，被认为与心血管疾病、代谢紊乱、认知功能障碍和行为改变的风险增加有关。牙周疾病是慢性感染性疾病，也被认为与心血管疾病、代谢综合征和认知功能障碍有关。几项研究表明，SDB可能通过炎症反应、氧化应激和口腔干燥等某些机制与牙周疾病相关。本系统评价的目的是以综合方法探讨SDB与牙周疾病之间的关联。
本系统评价将纳入通过电子和手工检索确定的队列研究、横断面研究和病例对照研究。将在以下数据库中进行电子检索：PubMed、Embase、Scopus和Web of Science。我们的检索将涵盖从数据库建立到2022年3月发表的文章，不受语言和研究背景限制。预先确定的纳入标准包括：参与者（无呼吸系统疾病史、过去6个月内无牙周治疗史且无已知影响SDB或牙周疾病的用药史）；暴露因素（已被诊断为SDB或SDB高危者）；对照（无SDB的参与者）；结局指标（牙周参数，如探诊深度、临床附着水平、探诊出血、影像学骨丧失）。两名作者将独立且重复地进行研究筛选和数据提取。所有分歧将通过讨论解决。将使用纽卡斯尔-渥太华量表评估纳入研究的方法学质量。
本系统评价将总结关于SDB与牙周疾病之间关联的现有证据，这是一个具有争议性和临床意义的话题。其研究结果可为制定相关预防和治疗策略提供证据。研究结果将通过同行评审期刊发表。
https://www.crd.york.ac.uk/PROSPERO/，标识符：CRD42022313024。于2022年3月28日注册。
