Adu Medard Kofi, Eboreime Ejemai, Sapara Adegboyega Oyekunbi, Agyapong Vincent Israel Opoku
Department of Psychiatry, University of Alberta, Edmonton, AB T6G 2B7, Canada.
Department of Psychiatry, Dalhousie University, Halifax, NS B3H 2E2, Canada.
Behav Sci (Basel). 2022 Jul 30;12(8):263. doi: 10.3390/bs12080263.
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that involves the application of magnetic pulses on hyperactive or hypoactive cortical brain areas. rTMS is considered a high therapeutic tool in many neuropsychiatric conditions. Despite its wide and continuous usage for the treatment of psychiatric disorders, information about the use of rTMS in bipolar disorders is limited and not well-established in the literature. This scoping review aims to explore the literature available regarding the application of rTMS for the management of bipolar disorders, to garner evidence in support of it uses in the management of bipolar disorders, and for recommendations on future clinical and research work. We electronically conducted a data search in five research databases (MEDLINE, CINAHL, Psych INFO, SCOPUS, and EMBASE) using all identified keywords across all the databases to identify evidence-based studies. Articles were included if they were published randomized control designs aimed at the use of rTMS in the management of bipolar disorders. Overall, nine studies were eligible for this review. The search results are up to date as of the final date of data search-20 December 2020. Only full-text published articles written in English were reviewed. Review articles on treatment with rTMS for conditions either than bipolar disorders were excluded. The application of rTMS intervention for bipolar disorders looks promising despite the diversity of its outcomes and its clinical significance. However, to be able to draw a definite conclusion on the clinical effectiveness of the technique, more randomized controlled studies with well-defined stimulation parameters need to be conducted with large sample sizes in the future.
重复经颅磁刺激(rTMS)是一种非侵入性神经调节技术,涉及对活跃过度或活跃不足的大脑皮质区域施加磁脉冲。rTMS在许多神经精神疾病中被视为一种高效的治疗工具。尽管其在治疗精神疾病方面得到广泛且持续的应用,但关于rTMS在双相情感障碍中的应用信息有限,且在文献中尚未得到充分确立。本范围综述旨在探索有关rTMS应用于双相情感障碍管理的现有文献,收集支持其用于双相情感障碍管理的证据,并为未来的临床和研究工作提供建议。我们在五个研究数据库(MEDLINE、CINAHL、Psych INFO、SCOPUS和EMBASE)中进行了电子数据搜索,使用所有数据库中确定的关键词来识别基于证据的研究。如果文章发表的是针对rTMS用于双相情感障碍管理的随机对照设计,则纳入研究。总体而言,有九项研究符合本综述的条件。搜索结果截至数据搜索的最终日期——2020年12月20日。仅对以英文撰写的全文发表文章进行了综述。排除了关于rTMS治疗双相情感障碍以外疾病的综述文章。尽管rTMS干预在双相情感障碍中的应用结果存在多样性及其临床意义,但看起来很有前景。然而,为了能够就该技术的临床有效性得出明确结论,未来需要进行更多具有明确刺激参数的大样本随机对照研究。
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