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从大流行中理解迷走神经在健康中的关键作用。

Understanding the Pivotal Role of the Vagus Nerve in Health from Pandemics.

作者信息

Rangon Claire-Marie, Niezgoda Adam

机构信息

Child Neurologist and Pain Specialist, INWE'CARE Medical Center, 92210 Saint-Cloud, France.

Chair and Department of Neurology, University of Medical Sciences, 60-355 Poznań, Poland.

出版信息

Bioengineering (Basel). 2022 Jul 29;9(8):352. doi: 10.3390/bioengineering9080352.

DOI:10.3390/bioengineering9080352
PMID:36004877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9405360/
Abstract

The COVID-19 pandemic seems endless with the regular emergence of new variants. Is the SARS-CoV-2 virus particularly evasive to the immune system, or is it merely disrupting communication between the body and the brain, thus pre-empting homeostasis? Retrospective analysis of the COVID-19 and AIDS pandemics, as well as prion disease, emphasizes the pivotal but little-known role of the 10th cranial nerve in health. Considering neuroimmunometabolism from the point of view of the vagus nerve, non-invasive bioengineering solutions aiming at monitoring and stimulating the vagal tone are subsequently discussed as the next optimal and global preventive treatments, far beyond pandemics.

摘要

随着新冠病毒新变种的不断出现，新冠疫情似乎没完没了。是严重急性呼吸综合征冠状病毒2（SARS-CoV-2）特别难以被免疫系统识别，还是它仅仅干扰了身体与大脑之间的通讯，从而破坏了体内平衡？对新冠疫情、艾滋病疫情以及朊病毒疾病的回顾性分析，凸显了第十对脑神经在健康方面关键却鲜为人知的作用。从迷走神经的角度考虑神经免疫代谢，随后将讨论旨在监测和刺激迷走神经张力的非侵入性生物工程解决方案，这些方案作为下一个最佳的全面预防性治疗手段，其作用远远不止于应对疫情。

相似文献

[1]
Understanding the Pivotal Role of the Vagus Nerve in Health from Pandemics.

Bioengineering (Basel). 2022-7-29

[2]
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[3]
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[4]
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[5]
Can neuromodulation support the fight against the COVID19 pandemic? Transcutaneous non-invasive vagal nerve stimulation as a potential targeted treatment of fulminant acute respiratory distress syndrome.

Med Hypotheses. 2020-7-18

[6]
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[7]
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[9]
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[10]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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本文引用的文献

[1]
A pilot randomized controlled trial of supervised, at-home, self-administered transcutaneous auricular vagus nerve stimulation (taVNS) to manage long COVID symptoms.

Bioelectron Med. 2022-8-25

[2]
Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients.

Front Neurol. 2022-7-14

[3]
Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors.

Int J Mol Sci. 2022-7-22

[4]
Development of a Smartphone-Based Expert System for COVID-19 Risk Prediction at Early Stage.

Bioengineering (Basel). 2022-6-27

[5]
[Long COVID: Pathogenesis and Therapeutic Approach].

Brain Nerve. 2022-7

[6]
Percutaneous Auricular Vagus Nerve Stimulation Reduces Inflammation in Critical Covid-19 Patients.

Front Physiol. 2022-7-4

[7]
Heart Rate as a Non-Invasive Biomarker of Inflammation: Implications for Digital Health.

Front Immunol. 2022-6-2

[8]
Strategies for precision vagus neuromodulation.

Bioelectron Med. 2022-5-30

[9]
A Deep Learning Approach for the Morphological Recognition of Reactive Lymphocytes in Patients with COVID-19 Infection.

Bioengineering (Basel). 2022-5-23

[10]
Monkeypox goes global: why scientists are on alert.

Nature. 2022-6

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