Mirna Moritz, Schmutzler Lukas, Vogl Fabian, Topf Albert, Hoppe Uta C, Lichtenauer Michael
Department of Internal Medicine II, Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria.
J Cardiovasc Dev Dis. 2022 Aug 22;9(8):283. doi: 10.3390/jcdd9080283.
Background: Tei index (TI) is a combined myocardial performance index, which was found to be more sensitive for overall cardiac dysfunction than systolic or diastolic parameters alone. Currently, there is only limited evidence for this measure in the context of myocarditis. Thus, TI could add additional benefits to conventional diagnostic workup. Methods: TI of patients with myocarditis (n = 40), acute coronary syndrome (n = 29) and controls (n = 50) was retrospectively analyzed concerning its discriminatory ability for myocarditis. Results: TI was most pathological in patients with myocarditis (median 0.41 vs. 0.35 vs. 0.31, p < 0.0001). Its discriminatory ability was better than that of EF or E/e’ (AUCs: TI: 0.71, p < 0.0001; EF: 0.57, p = 0.112; E/e’: 0.64, p = 0.983), which was also verified in logistic regression analysis (B(SE) = 0.81(0.23), p = 0.0004). The association of TI with myocarditis remained significant even after correction for confounders in propensity score weighted analysis. Conclusions: The TI showed a better discriminatory ability for myocarditis than conventional echocardiographic parameters. Since TI is easily conducted, it might be a helpful adjunctive tool to supplement conventional diagnostic modalities in patients with suspected myocarditis.
Tei指数（TI）是一种综合心肌性能指数，已发现其对整体心脏功能障碍的敏感性高于单独的收缩期或舒张期参数。目前，在心肌炎背景下关于该指标的证据有限。因此，TI可能为传统诊断检查带来额外益处。方法：回顾性分析心肌炎患者（n = 40）、急性冠状动脉综合征患者（n = 29）和对照组（n = 50）的TI，以评估其对心肌炎的鉴别能力。结果：心肌炎患者的TI最具病理性（中位数0.41 vs. 0.35 vs. 0.31，p < 0.0001）。其鉴别能力优于EF或E/e’（曲线下面积：TI：0.71，p < 0.0001；EF：0.57，p = 0.112；E/e’：0.64，p = 0.983），这在逻辑回归分析中也得到验证（B(SE) = 0.81(0.23)，p = 0.0004）。在倾向评分加权分析中校正混杂因素后，TI与心肌炎的关联仍然显著。结论：TI对心肌炎的鉴别能力优于传统超声心动图参数。由于TI操作简便，它可能是一种有用的辅助工具，用于补充疑似心肌炎患者的传统诊断方法。
