Departments of Neurology and.
Pathology (Neuropathology), University of Pittsburgh School of Medicine, Pittsburgh, PA.
J Clin Neuromuscul Dis. 2022 Sep 1;24(1):38-48. doi: 10.1097/CND.0000000000000428.
We cover intensive care unit-acquired neuromuscular disorders associated with coronavirus disease 2019. Outcomes may be worse than expected in these patients, and there is some evidence that coronavirus disease 2019 causes myopathy directly. Corticosteroid regimens in Duchenne muscular dystrophy are addressed including outcomes in pulmonary and cardiac function. A recent article notes a continued diagnostic delay in Duchenne muscular dystrophy. An interesting report of a Canary Islands cohort of patients with oculopharyngeal muscular dystrophy is discussed. Features and clinical pearls related to a series of patients with limb-girdle muscle dystrophy R12 (anoctaminopathy) and a misdiagnosis of idiopathic inflammatory myopathy are provided. The last section on autoimmune myopathy includes articles on clinical and pathologic features associated with myositis-specific antibodies and dermatomyositis, the epidemiology of immune-mediated necrotizing myopathies (IMNMs) in Olmsted County, Minnesota, and features of a German cohort of hydroxy-3-methylglutaryl coenzyme A reductase-associated IMNM. A recent article proposes the benefit of early intravenous immunoglobulin use for adults with IMNM. We also highlight a report of 2 unusual cases of antisignal recognition particle myopathy presenting with asymmetric distal weakness.
我们涵盖了与 2019 年冠状病毒病相关的重症监护病房获得性神经肌肉疾病。这些患者的预后可能比预期的更差，有一些证据表明 2019 年冠状病毒病会直接导致肌病。文中还提到了杜氏肌营养不良症的皮质类固醇治疗方案，包括对肺和心脏功能的影响。最近的一篇文章指出，杜氏肌营养不良症的诊断仍存在延迟。文中还讨论了一个关于加那利群岛眼咽型肌营养不良症患者队列的有趣报告。提供了一系列肢带型肌营养不良症 R12（伴肌管病）患者和误诊为特发性炎性肌病的病例的特征和临床要点。自身免疫性肌病的最后一部分包括与肌炎特异性抗体和皮肌炎相关的临床和病理特征、明尼苏达州奥姆斯特德县免疫介导的坏死性肌病（IMNM）的流行病学以及羟甲基戊二酰辅酶 A 还原酶相关 IMNM 的德国队列特征的相关文章。最近的一篇文章提出了早期静脉注射免疫球蛋白治疗 IMNM 成人患者的益处。我们还强调了一份关于以不对称远端无力为表现的 2 例不常见抗信号识别颗粒肌病报告。
