Lina Robin, Lepine Olivier, Jaouen Pascal, Masse Anthony
AlgoSource, 7 rue Eugene Cornet, F-44600 Saint-Nazaire, France.
Nantes Université, Oniris, Centre National de la Recherche Scientifique, GEPEA, UMR 6144, F-44600 Saint-Nazaire, France.
Membranes (Basel). 2022 Aug 5;12(8):766. doi: 10.3390/membranes12080766.
This work aims at studying the techno-economic feasibility to produce an extract, at a small industrial-production scale, from a 's paste, in view of cosmetic applications. The paste was first thawed, diluted and centrifuged to get a crude water extract. Then, two successive stages of membrane filtration were carried out: the first one to essentially remove/retain the particles (cellular debris) by microfiltration and the second one to concentrate (ultrafiltration) the soluble compounds of the permeate from the previous step. The robustness of the processing chain has been demonstrated following the production of three similar extracts with more than 30 L input material each. Around 54% of the final extract was composed of proteins and carbohydrates. The final ingredient was assessed for genomic activity and showed multiple positive responses. Finally, an economic analysis was performed, which demonstrated that the major cost is linked to centrifugation step. The total manpower represents the highest cost of the OPEX categories.
这项工作旨在研究以小规模工业生产规模从一种“s糊状物”中提取提取物用于化妆品应用的技术经济可行性。首先将糊状物解冻、稀释并离心以获得粗水提取物。然后进行两个连续的膜过滤阶段：第一个阶段通过微滤基本上去除/保留颗粒（细胞碎片），第二个阶段对前一步渗透液中的可溶性化合物进行浓缩（超滤）。在生产了三种每种输入材料超过30升的类似提取物之后，证明了加工链的稳健性。最终提取物约54%由蛋白质和碳水化合物组成。对最终成分进行了基因组活性评估，结果显示有多种阳性反应。最后进行了经济分析，结果表明主要成本与离心步骤有关。总人力成本是运营支出类别中最高的成本。
