Department of Gynaecology, First Affiliated Hospital of Harbin Medical University, Harbin, P. R. China.
Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, P. R. China.
Biomed Chromatogr. 2022 Dec;36(12):e5490. doi: 10.1002/bmc.5490. Epub 2022 Sep 9.
The onset of complex diseases at a later stage of life has been linked with maternal folic acid (FA) ingestion. However, little is known regarding the underlying molecular fingerprints of the offspring. We integrated proteomics-metabolomics profiles and analyzed the influence of maternal FA supplementation on the metabolism of adult offspring rats. Twenty pregnant female rats were randomly assigned to a FA supplementation (FolS group, 10 mg/kg FA) or control group (2 mg/kg FA respectively). Such an omics approach revealed that the dopaminergic synapse pathway, tricarboxylic acid cycle and neural development-related metabolites such as glutamic acid and γ-aminobutyric acid were significantly up-regulated in the FolS group, whereas pyruvic acid, oxalic acid and adipic acid were reduced. Maternal FA supplementation can cause alterations of metabolites and protein in the offspring rats.
生命后期复杂疾病的发病与母体叶酸（FA）摄入有关。然而，对于后代潜在的分子指纹知之甚少。我们整合了蛋白质组学-代谢组学图谱，并分析了母体 FA 补充对成年后代大鼠代谢的影响。20 只怀孕雌性大鼠被随机分配到 FA 补充组（FolS 组，10mg/kg FA）或对照组（分别为 2mg/kg FA）。这种组学方法表明，多巴胺能突触途径、三羧酸循环和与神经发育相关的代谢物，如谷氨酸和γ-氨基丁酸，在 FolS 组中显著上调，而丙酮酸、草酸和己二酸则减少。母体 FA 补充可导致后代大鼠代谢物和蛋白质的改变。
