Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Toxins (Basel). 2022 Jul 28;14(8):516. doi: 10.3390/toxins14080516.
Paralytic shellfish toxins (PSTs) are an increasingly important source of pollution. Bivalves, as the main transmission medium, accumulate and metabolize PSTs while protecting themselves from damage. At present, the resistance mechanism of bivalves to PSTs is unclear. In this study, and were used as experimental shellfish species for in situ monitoring. We compared the inflammatory-related gene responses of the two shellfish during PSTs exposure by using transcriptomes. The results showed that the accumulation and metabolism rate of PSTs in was five-fold higher than that in . The inflammatory balance mechanism of involved the co-regulation of the MAPK-based and AMPK-based anti-inflammatory pathways. bore a higher risk of death because it did not have the balance system, and the regulation of apoptosis-related pathways such as the PI3K-AKT signaling pathway were upregulated. Taken together, the regulation of the inflammatory balance coincides with the ability of bivalves to cope with PSTs. Inflammation is an important factor that affects the metabolic pattern of PSTs in bivalves. This study provides new evidence to support the studies on the resistance mechanism of bivalves to PSTs.
麻痹性贝类毒素（PSTs）是一种日益重要的污染来源。双壳类动物作为主要的传播介质，在保护自身免受伤害的同时，积累和代谢 PSTs。目前，双壳类动物对 PSTs 的抗性机制尚不清楚。在这项研究中，和 被用作实验贝类进行原位监测。我们通过转录组比较了两种贝类在 PSTs 暴露下的炎症相关基因反应。结果表明，在 PSTs 暴露下，的 PSTs 积累和代谢率是 的五倍。的炎症平衡机制涉及基于 MAPK 和基于 AMPK 的抗炎途径的共同调节。因为没有平衡系统，所以 面临更高的死亡风险，并且上调了凋亡相关途径（如 PI3K-AKT 信号通路）的调节。综上所述，炎症平衡的调节与双壳类动物应对 PSTs 的能力相一致。炎症是影响双壳类动物 PSTs 代谢模式的重要因素。本研究为双壳类动物对 PSTs 抗性机制的研究提供了新的证据支持。
