Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, 750004, China.
Department of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, 750004, China.
Biol Trace Elem Res. 2023 Jun;201(6):2895-2903. doi: 10.1007/s12011-022-03393-2. Epub 2022 Aug 25.
Magnesium ions are essential elements to the human body, with a daily intake of about 350 mg for an adult. Recently, a meta-analysis reported that magnesium ion intake is related to a reduced risk of colorectal tumors. In addition, implantation of biodegradable magnesium pins after colorectal tumor resection could potentially inhibit the residual tumor cells. These impressive results implied that magnesium ions possess inhibitory properties against colorectal carcinoma. However, this hypothesis has yet to be confirmed by experimental results. In this work, different concentrations of magnesium ions were modulated to investigate their inhibitory effects on cell viability through cell cycle arrest, subsequently inducing apoptosis by activating the caspase-3 pathway. The animal experiments revealed that magnesium injection restricted tumor growth after 3 weeks of treatment compared to the control group. According to the immunohistochemistry and transmission electron microscopy results, the remarkable effect may be attributed to promoting the apoptotic rate of tumor cells. The evidence highlights the potential for the clinical use of magnesium implants to inhibit the growth of residual cells after colorectal tumor surgery.
镁离子是人体必需的元素，成年人每天的摄入量约为 350mg。最近，一项荟萃分析报告称，镁离子的摄入与结直肠肿瘤风险的降低有关。此外，在结直肠肿瘤切除术后植入可生物降解的镁钉可能会抑制残留的肿瘤细胞。这些令人印象深刻的结果表明，镁离子对结直肠癌具有抑制作用。然而，这一假设尚未得到实验结果的证实。在这项工作中，通过细胞周期阻滞调节不同浓度的镁离子，研究它们对细胞活力的抑制作用，随后通过激活 caspase-3 途径诱导细胞凋亡。动物实验表明，与对照组相比，镁注射在治疗 3 周后限制了肿瘤的生长。根据免疫组织化学和透射电子显微镜的结果，这种显著的效果可能归因于促进肿瘤细胞的凋亡率。这些证据突出了镁植入物在临床上用于抑制结直肠肿瘤手术后残留细胞生长的潜力。
