Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Pain Research Center, Department of Anesthesiology and Pain Medicine, Iran University of Medical Sciences, Tehran, Iran.
Cancer Med. 2024 Sep;13(17):e70171. doi: 10.1002/cam4.70171.
Therapeutic management of colorectal cancer (CRC) does not yet yield promising long-term results. Therefore, there is a need for further investigation of possible therapeutic options. Various experiments have studied the effects of apigenin on CRC and have shown conflicting results. This systematic review and meta-analysis investigates the currently existing evidence on the effect of apigenin on CRC.
Medline, Embase, Scopus, and Web of Science databases were searched for articles related to apigenin and its effect on CRC in the preclinical setting. Cell viability, growth inhibition, apoptosis, and cell cycle arrest for in-vitro, and body weight, tumor size, and mortality in in-vivo studies were extracted as outcomes.
Thirty-nine articles investigating colorectal adenocarcinoma were included in this meta-analysis. Thirty-seven of these studies had data for in vitro experiments, with eight studies having data for in vivo experiments. Six articles had both in vitro and in vivo assessments. Our analysis showed apigenin reduces cell viability and induces growth inhibition, apoptosis, and cell cycle arrest in in vitro studies. The few in vivo studies indicate that apigenin decreases tumor size while showing no effects on the body weight of animal colorectal adenocarcinoma models.
Our results demonstrated that apigenin, through reducing cell viability, inducing growth inhibition, apoptosis, and cell cycle arrest, and also by decreasing the tumor size, can be considered as a possible adjuvant agent in the management of colorectal adenocarcinoma. However, further in vivo studies are needed before any efforts to translate the current evidence into clinical studies.
结直肠癌（CRC）的治疗管理尚未产生有希望的长期结果。因此，需要进一步研究可能的治疗选择。各种实验已经研究了芹菜素对 CRC 的影响，并且得出了相互矛盾的结果。本系统评价和荟萃分析调查了目前关于芹菜素对 CRC 影响的证据。
检索了 Medline、Embase、Scopus 和 Web of Science 数据库，以获取与芹菜素及其在临床前环境中对 CRC 影响相关的文章。提取细胞活力、生长抑制、凋亡和细胞周期停滞的体外结果，以及体内研究的体重、肿瘤大小和死亡率。
本荟萃分析纳入了 39 篇研究结直肠腺癌的文章。其中 37 项研究具有体外实验数据，8 项研究具有体内实验数据。6 篇文章既有体外也有体内评估。我们的分析表明，芹菜素可降低体外研究中的细胞活力并诱导生长抑制、凋亡和细胞周期停滞。少数体内研究表明，芹菜素可减小肿瘤大小，而对动物结直肠腺癌模型的体重没有影响。
我们的结果表明，芹菜素通过降低细胞活力、诱导生长抑制、凋亡和细胞周期停滞，以及减小肿瘤大小，可以被认为是结直肠腺癌管理的一种潜在辅助剂。然而，在将当前证据转化为临床研究之前，需要进行更多的体内研究。
