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共注射的DNA序列之间的同源重组在S期早期至中期达到峰值。

Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase.

作者信息

Wong E A, Capecchi M R

出版信息

Mol Cell Biol. 1987 Jun;7(6):2294-5. doi: 10.1128/mcb.7.6.2294-2295.1987.

DOI:10.1128/mcb.7.6.2294-2295.1987
PMID:3600663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC365354/
Abstract

We have examined the effect of cell cycle position on homologous recombination between plasmid molecules coinjected into synchronized rat fibroblasts. Recombination activity was found to be low in G1 and to rise 10- to 15-fold, peaking in early to mid-S phase.

摘要

我们研究了细胞周期位置对共注射到同步化大鼠成纤维细胞中的质粒分子间同源重组的影响。发现重组活性在G1期较低，在S期早期至中期升高10至15倍，达到峰值。

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本文引用的文献

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Recombination during gene transfer into mouse cells can restore the function of deleted genes.在将基因导入小鼠细胞的过程中发生的重组可以恢复缺失基因的功能。
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Homologous recombination in mammalian cells mediates formation of a functional gene from two overlapping gene fragments.哺乳动物细胞中的同源重组介导了由两个重叠基因片段形成一个功能基因的过程。
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