血小板黏附受体的翻译后修饰。
Posttranslational modifications of platelet adhesion receptors.
作者信息
Sun Shukun, Qiao Bao, Han Yu, Wang Bailu, Wei Shujian, Chen Yuguo
机构信息
Department of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China; Clinical Research Center for Emergency and Critical Care Medicine of Shandong Province, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Clinical Trial Center, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
出版信息
Pharmacol Res. 2022 Sep;183:106413. doi: 10.1016/j.phrs.2022.106413. Epub 2022 Aug 23.
Platelets play a key role in normal hemostasis, whereas pathological platelet adhesion is involved in various cardiovascular events. The underlying cause in cardiovascular events involves plaque rupture leading to subsequent platelet adhesion, activation, release, and eventual thrombosis. Traditional antithrombotic drugs often target the signal transduction process of platelet adhesion receptors by influencing the synthesis of some key molecules, and their effects are limited. Posttranslational modifications (PTMs) of platelet adhesion receptors increase the functional diversity of the receptors and affect platelet physiological and pathological processes. Antithrombotic drugs targeting PTMs of platelet adhesion receptors may represent a new therapeutic idea. In this review, various PTMs, including phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, lipidation, and proteolysis, of three platelet adhesion receptors, glycoprotein Ib-IX-V (GPIb-IX-V), glycoprotein VI (GPVI), and integrin αβ are reviewed. It is important to comprehensively understand the PTMs process of platelet adhesion receptors.
血小板在正常止血过程中起关键作用，而病理性血小板黏附则参与各种心血管事件。心血管事件的潜在原因包括斑块破裂，导致随后的血小板黏附、激活、释放以及最终形成血栓。传统抗血栓药物通常通过影响一些关键分子的合成来靶向血小板黏附受体的信号转导过程，但其效果有限。血小板黏附受体的翻译后修饰（PTM）增加了受体的功能多样性，并影响血小板的生理和病理过程。靶向血小板黏附受体PTM的抗血栓药物可能代表一种新的治疗思路。在本综述中，对三种血小板黏附受体，即糖蛋白Ib-IX-V（GPIb-IX-V）、糖蛋白VI（GPVI）和整合素αβ的各种PTM进行了综述，包括磷酸化、糖基化、泛素化、亚硝基化、甲基化、脂化和蛋白水解。全面了解血小板黏附受体的PTM过程非常重要。
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