Division of Cardiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
University Psychiatric Centre, Katholieke Universiteit, Kortenberg, Belgium; Department of Neurosciences, Centre for Clinical Psychiatry, Katholieke Universiteit Leuven, Leuven, Belgium; Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven, Belgium; Antwerp Health Law and Ethics Chair, University of Antwerp, Antwerp, Belgium.
J Am Coll Cardiol. 2022 Aug 30;80(9):918-933. doi: 10.1016/j.jacc.2022.06.017.
People with severe mental illness, consisting of schizophrenia, bipolar disorder, and major depression, have a high burden of modifiable cardiovascular risk behaviors and conditions and have a cardiovascular mortality rate twice that of the general population. People with acute and chronic cardiovascular disease are at a higher risk of developing mental health symptoms and disease. There is emerging evidence for shared etiological factors between severe mental illness and cardiovascular disease that includes biological, genetic, and behavioral mechanisms. This state-of-the art review will describe the relationship between severe mental illness and cardiovascular disease, explore the factors that lead to poor cardiovascular outcomes in people with severe mental illness, propose strategies to improve the cardiovascular health of people with severe mental illness, and present areas for future research focus.
患有严重精神疾病的人，包括精神分裂症、双相情感障碍和重度抑郁症，具有较高的可改变心血管风险行为和状况的负担，其心血管死亡率是普通人群的两倍。患有急性和慢性心血管疾病的人患心理健康症状和疾病的风险更高。越来越多的证据表明，严重精神疾病和心血管疾病之间存在共同的病因因素，包括生物学、遗传学和行为机制。本综述将描述严重精神疾病与心血管疾病之间的关系，探讨导致严重精神疾病患者心血管结局不良的因素，提出改善严重精神疾病患者心血管健康的策略，并提出未来研究重点领域。
