硫利达嗪及其主要代谢物的游离血浆浓度、总血浆浓度和红细胞浓度：一项体外研究。

Unbound plasma concentrations, total plasma concentrations, and red blood cell concentrations of thioridazine and its main metabolites: an in vitro study.

作者信息

Nyberg G, Mårtensson E

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1987 Apr;335(4):465-8. doi: 10.1007/BF00165564.

Abstract

The relationships between, on the one hand, the unbound plasma concentrations of thioridazine and thioridazine metabolites and, on the other, the total plasma concentrations and the red blood cell concentrations were studied in vitro. The relationships between the unbound and total plasma concentrations were curvilinear, while those between the unbound concentrations and the red blood cell concentrations within a broad range were closer to rectilinear. Profound changes were seen in the relationship between unbound and total plasma concentrations at varying concentrations of alpha 1-acid glycoprotein, while the rectilinear relationship between the unbound plasma concentrations and the red blood cell concentrations remained essentially unchanged.

摘要

一方面研究了硫利达嗪及其代谢产物的游离血浆浓度与另一方面总血浆浓度和红细胞浓度之间的关系。游离血浆浓度与总血浆浓度之间的关系呈曲线状，而在很宽范围内游离浓度与红细胞浓度之间的关系更接近直线状。在不同浓度的α1-酸性糖蛋白条件下，游离血浆浓度与总血浆浓度之间的关系出现了显著变化，而游离血浆浓度与红细胞浓度之间的直线关系基本保持不变。