Vasil'eva L A, Zotova E G
Neirofiziologiia. 1987;19(2):147-56.
Background and evoked neuronal activity of the sensorimotor cortex was studied in cats under chloralose anaesthesia. Click, flashes and shocks applied to the contralateral forepaw were used as stimuli. Paired heteromodal stimuli were presented with interstimulus intervals of 0, 100, 200, 300 and 400 ms. Stimuli of different modality completely or partly blocked the response to the testing stimulus when the interstimulus interval was 100-200 ms. The maximum response to the second stimulus followed 200-300 ms after the first stimulus. To study the intercortical mechanisms of heterosensory interaction picrotoxin (antagonist of inhibitory neurotransmitter) was locally applied to the studied neuron. Picrotoxin application produced reduction of the blocking period after the conditioning stimulus and appearance of a response to the testing stimulus at shorter interstimulus intervals compared with those observed before application. In some cells an increase in the number of spikes in a burst at one interstimulus interval or an even rise in the response at several interstimulus intervals were observed. The question about the role of intracortical inhibitory influences on the mechanisms of heterosensory interaction on neurons of the sensorimotor cortex is discussed on the basis of the obtained data.
在水合氯醛麻醉下，对猫的感觉运动皮层的背景和诱发神经元活动进行了研究。对侧前爪施加的点击、闪光和电击用作刺激。成对的异模态刺激以0、100、200、300和400毫秒的刺激间隔呈现。当刺激间隔为100 - 200毫秒时，不同模态的刺激完全或部分阻断了对测试刺激的反应。对第二个刺激的最大反应在第一个刺激后200 - 300毫秒出现。为了研究异感觉相互作用的皮质间机制，将印防己毒素（抑制性神经递质的拮抗剂）局部应用于所研究的神经元。与应用前观察到的情况相比，应用印防己毒素使条件刺激后的阻断期缩短，并在更短的刺激间隔出现对测试刺激的反应。在一些细胞中，观察到在一个刺激间隔时爆发中的峰电位数量增加，或者在几个刺激间隔时反应甚至增强。基于获得的数据，讨论了皮质内抑制性影响在感觉运动皮层神经元异感觉相互作用机制中的作用问题。
