Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
The First Clinical College of Gannan Medical University, Ganzhou 341000, China.
Biomolecules. 2022 Jul 28;12(8):1040. doi: 10.3390/biom12081040.
has received extensive attention in recent years as one prospective oncogene with tumor-promoting features in many malignancies. ATAD2 is a highly conserved bromodomain family protein that exerts its biological functions by mainly AAA ATPase and bromodomain. ATAD2 acts as an epigenetic decoder and transcription factor or co-activator, which is engaged in cellular activities, such as transcriptional regulation, DNA replication, and protein modification. ATAD2 has been reported to be highly expressed in a variety of human malignancies, including gastrointestinal malignancies, reproductive malignancies, urological malignancies, lung cancer, and other types of malignancies. ATAD2 is involved in the activation of multiple oncogenic signaling pathways and is closely associated with tumorigenesis, progression, chemoresistance, and poor prognosis, but the oncogenic mechanisms vary in different cancer types. Moreover, the direct targeting of ATAD2's bromodomain may be a very challenging task. In this review, we summarized the role of ATAD2 in various types of malignancies and pointed out the pharmacological direction.
近年来，作为一种具有肿瘤促进特征的潜在癌基因，ATAD2 受到了广泛关注。ATAD2 是一种高度保守的溴结构域家族蛋白，主要通过 AAA ATPase 和溴结构域发挥其生物学功能。ATAD2 作为一种表观遗传解码器和转录因子或共激活因子，参与细胞活动，如转录调控、DNA 复制和蛋白质修饰。已有报道称，ATAD2 在多种人类恶性肿瘤中高度表达，包括胃肠道恶性肿瘤、生殖系统恶性肿瘤、泌尿系统恶性肿瘤、肺癌和其他类型的恶性肿瘤。ATAD2 参与多种致癌信号通路的激活，与肿瘤发生、进展、化疗耐药和预后不良密切相关，但在不同癌症类型中的致癌机制有所不同。此外，直接靶向 ATAD2 的溴结构域可能是一项极具挑战性的任务。在这篇综述中，我们总结了 ATAD2 在各种类型恶性肿瘤中的作用，并指出了药理学方向。
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