血浆 P-Tau181 用于鉴别阿尔茨海默病与其他原发性痴呆和/或运动障碍。

Plasma P-Tau181 for the Discrimination of Alzheimer's Disease from Other Primary Dementing and/or Movement Disorders.

机构信息

2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, "Attikon" General University Hospital, 12462 Athens, Greece.

Neurochemistry and Biological Markers Unit, 1st Department of Neurology, "Eginition" Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.

出版信息

Biomolecules. 2022 Aug 10;12(8):1099. doi: 10.3390/biom12081099.

DOI:10.3390/biom12081099

PMID:36008993

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9405977/

Abstract

Blood phospho-tau181 may offer a useful biomarker for Alzheimer's disease. However, the use of either serum or plasma phospho-tau181 and their diagnostic value are currently under intense investigation. In a pilot study, we measured both serum and plasma phospho-tau181 (pT181-Tau) by single molecule array (Simoa) in a group of patients with Alzheimer's disease and a mixed group of patients with other primary dementing and/or movement disorders. Classical cerebrospinal fluid biomarkers were also measured. Plasma (but not serum) pT181-Tau showed a significant increase in Alzheimer's disease and correlated significantly with cerebrospinal fluid amyloid and pT181-Tau. Receiver operating curve analysis revealed a significant discrimination of Alzheimer's from non-Alzheimer's disease patients, with an area under the curve of 0.83 and an excellent sensitivity but a moderate specificity. Plasma pT181-Tau is not an established diagnostic biomarker for Alzheimer's disease, but it could become one in the future, or it may serve as a screening tool for specific cases of patients or presymptomatic subjects.

摘要

血液磷酸化 tau181 可能是阿尔茨海默病的一个有用的生物标志物。然而，目前正在深入研究血清或血浆磷酸化 tau181 及其诊断价值。在一项初步研究中，我们通过单分子阵列（Simoa）测量了一组阿尔茨海默病患者和一组其他原发性痴呆症和/或运动障碍患者的血清和血浆磷酸化 tau181（pT181-Tau）。还测量了经典的脑脊液生物标志物。血浆（而非血清）pT181-Tau 在阿尔茨海默病中显著增加，并与脑脊液淀粉样蛋白和 pT181-Tau 显著相关。接收者操作曲线分析显示，阿尔茨海默病与非阿尔茨海默病患者的区分具有显著意义，曲线下面积为 0.83，具有良好的敏感性但中等的特异性。血浆 pT181-Tau 不是阿尔茨海默病的既定诊断生物标志物，但将来可能成为一种生物标志物，或者它可以作为特定病例或亚临床患者的筛查工具。