Poireau Margaux, Milpied Thomas, Maillard Angéline, Delmaire Christine, Volle Emmanuelle, Bellivier Frank, Icick Romain, Azuar Julien, Marie-Claire Cynthia, Bloch Vanessa, Vorspan Florence
Département de Pharmacie, Université de Paris Cité, Inserm UMR-S 1144, Optimisation Thérapeutique en Neurospsychopharmacologie, OTeN, F-75006 Paris, France.
Département de Psychiatrie et Médecine Addictologique, Hôpital Fernand Widal, Assistance Publique-Hôpitaux de Paris Nord, 75010 Paris, France.
Brain Sci. 2022 Jul 30;12(8):1013. doi: 10.3390/brainsci12081013.
Cocaine use disorder is a chronic disease with severe consequences and a high relapse rate. There is a critical need to explore the factors influencing relapse in order to achieve more efficient treatment outcomes. Furthermore, there is a great need for easy-to-measure, repeatable, and valid biomarkers that can predict treatment response or relapse.
We reviewed the available literature on the Pubmed database concerning the biomarkers associated with relapse in CUD, including central nervous system-derived, genetic, immune, oxidative stress, and "other" biomarkers.
Fifty-one articles were included in our analysis. Twenty-five imaging brain anatomic and function assessment studies, mostly using fMRI, examined the role of several structures such as the striatum activity in abstinence prediction. There were fewer studies assessing the use of neuropsychological factors, neurotrophins, or genetic/genomic factors, immune system, or oxidative stress measures to predict abstinence.
Several biomarkers have been shown to have predictive value. Prospective studies using combined multimodal assessments are now warranted.
可卡因使用障碍是一种具有严重后果且复发率高的慢性疾病。迫切需要探索影响复发的因素，以实现更有效的治疗效果。此外，非常需要易于测量、可重复且有效的生物标志物，能够预测治疗反应或复发。
我们检索了Pubmed数据库中有关与可卡因使用障碍复发相关生物标志物的现有文献，包括中枢神经系统来源的、遗传的、免疫的、氧化应激的以及“其他”生物标志物。
我们的分析纳入了51篇文章。25项脑成像解剖和功能评估研究，大多使用功能磁共振成像（fMRI），研究了纹状体活动等多个结构在禁欲预测中的作用。评估使用神经心理因素、神经营养因子、遗传/基因组因素、免疫系统或氧化应激指标来预测禁欲的研究较少。
已证明几种生物标志物具有预测价值。现在有必要开展使用联合多模式评估的前瞻性研究。
