Mizuiri S, Ozawa T, Hirata K, Takezawa K, Kawamura S
Nephron. 1987;46(1):23-7. doi: 10.1159/000184290.
Histological and ultrastructural studies of juxtaglomerular cells (JGC) were performed in a patient with pseudo-Bartter's syndrome due to furosemide abuse. The biopsy done before the treatment revealed a large number of secretory granules and mitochondria, dilated rough endoplasmic reticulum and a well-developed Golgi apparatus in JGC. The JGC granules, some of which contained crystalloid structures showed various shapes and sizes. In the biopsy carried out after the cessation of furosemide intake, these morphological changes were markedly improved with a reduced activity of the renin-angiotensin system. The characteristic changes of JGC may be valuable in determing the functional and morphological interrelations of this disorder.
对一名因滥用速尿导致假性巴特综合征患者的球旁细胞（JGC）进行了组织学和超微结构研究。治疗前进行的活检显示，JGC中有大量分泌颗粒和线粒体，粗面内质网扩张，高尔基体发达。JGC颗粒，其中一些含有晶体结构，呈现出各种形状和大小。在停止服用速尿后进行的活检中，随着肾素-血管紧张素系统活性降低，这些形态学变化明显改善。JGC的特征性变化可能对确定该疾病的功能和形态学相互关系具有重要价值。
