Genis-Mendoza Alma Delia, González-Castro Thelma Beatriz, Tovilla-Vidal Gisselle, Juárez-Rojop Isela Esther, Castillo-Avila Rosa Giannina, López-Narváez María Lilia, Tovilla-Zárate Carlos Alfonso, Sánchez-de la Cruz Juan Pablo, Fresán Ana, Nicolini Humberto
Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de México 14610, Mexico.
División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez 86040, Tabasco, Mexico.
Biomedicines. 2022 Aug 8;10(8):1919. doi: 10.3390/biomedicines10081919.
Glycosylated hemoglobin is used to diagnose type 2 diabetes mellitus and assess metabolic control. Depression itself has been associated with high levels of HbA1c in individuals with T2DM. The association between diabetes and depression suggests the usefulness of determining HbA1c as a biological marker of depressive symptoms. The aim of this study was to determine HbA1c levels in individuals with T2DM with vs. without depression. Additionally, we analyzed the influence of pharmacological treatments, time of evolution, and complications of disease. We performed a literature search in different databases published up to January 2020. A total of 34 articles were included. Our results showed that individuals with T2DM with depression showed increased levels of HbA1c in comparison to individuals with T2DM without depression (d = 0.18, 95% CI: 0.12−0.29, p(Z) < 0.001; I2 = 85.00). We also found that HbA1c levels remained elevated in individuals with T2DM with depression who were taking hypoglycemic drugs (d = 0.20 95% CI: 0.11−0.30, p(Z) < 0.001; I2 = 86.80), in individuals with less than 10 years of evolution (d = 0.17 95% CI: 0.09−0.26, p(Z) = 0.001; I2 = 66.03) and in individuals with complications of the disease (d = 0.17, 95% CI: 0.07−0.26, p(Z) < 0.001; I2 = 58.41). Our results show that HbA1c levels in individuals with T2DM with depression are significantly increased compared to controls with T2DM without depression. Additionally, these levels remained elevated in individuals who were taking hypoglycemic drugs, those with less than 10 years of disease evolution, and those with complications related to diabetes. It is necessary to examine the existence of a diabetes−HbA1c−depression connection.
糖化血红蛋白用于诊断2型糖尿病并评估代谢控制情况。抑郁症本身与2型糖尿病患者的高糖化血红蛋白水平有关。糖尿病与抑郁症之间的关联表明，将糖化血红蛋白作为抑郁症状的生物学标志物具有一定作用。本研究的目的是确定患有和未患有抑郁症的2型糖尿病患者的糖化血红蛋白水平。此外，我们分析了药物治疗、病程及疾病并发症的影响。我们在截至2020年1月发表的不同数据库中进行了文献检索。共纳入34篇文章。我们的结果显示，与未患抑郁症的2型糖尿病患者相比，患抑郁症的2型糖尿病患者的糖化血红蛋白水平升高（d = 0.18，95%置信区间：0.12−0.29，p(Z) < 0.001；I2 = 85.00）。我们还发现，正在服用降糖药的患抑郁症的2型糖尿病患者（d = 0.20，95%置信区间：0.11−0.30，p(Z) < 0.001；I2 = 86.80）、病程少于10年的患者（d = 0.17，95%置信区间：0.09−0.26，p(Z) = 0.001；I2 = 66.03）以及患有疾病并发症的患者（d = 0.17，95%置信区间：0.07−0.26，p(Z) < 0.001；I2 = 58.41）的糖化血红蛋白水平仍然升高。我们的结果表明，与未患抑郁症的2型糖尿病对照组相比，患抑郁症的2型糖尿病患者的糖化血红蛋白水平显著升高。此外，正在服用降糖药的患者、病程少于10年的患者以及患有糖尿病相关并发症的患者的糖化血红蛋白水平仍然升高。有必要研究糖尿病-糖化血红蛋白-抑郁症之间的联系是否存在。
Zotero 插件
