[具体物质]对2型糖尿病患者代谢指标的影响：一项临床试验的系统评价与荟萃分析

Effects of on Metabolic Profiles in Type 2 Diabetes: A Systematic Review and Meta-analysis of Clinical Trials.

作者信息

Tabrizi Reza, Sekhavati Eghbal, Nowrouzi-Sohrabi Peyman, Rezaei Shahla, Tabari Parinaz, Ghoran Salar Hafez, Jamali Navid, Jalali Mohammad, Moosavi Mahsa, Kolahi Ali-Asghar, Bettampadi Deepti, Sahebkar Amirhossein, Safiri Saeid

机构信息

Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.

Clinical Research Development Unit of Vali Asr Hospital, Fasa University of Medical Sciences, Fasa, Iran.

出版信息

Mini Rev Med Chem. 2022;22(3):550-563. doi: 10.2174/1389557521666210929143112.

DOI:10.2174/1389557521666210929143112

PMID:34587883

Abstract

BACKGROUND

Several studies have investigated the effect of Urtica dioica (UD) consumption on metabolic profiles in patients with type 2 diabetes mellitus (T2DM); however, the findings are inconsistent. This systematic review and meta-analysis of clinical trials were performed to summarize the evidence of the effects of UD consumption on metabolic profiles in patients with T2DM.

METHODS

Eligible studies were retrieved from searches of PubMed, Embase, Scopus, Web of Science, Cochrane Library, and Google Scholar databases until December 2019. Cochran (Q) and I-square statistics were used to examine heterogeneity across included clinical trials. Data were pooled using a fixed-effect or random-effects model and expressed as weighted mean difference (WMD) and 95% confidence interval (CI).

RESULTS

Among 1485 citations, thirteen clinical trials were found to be eligible for the current metaanalysis. UD consumption significantly decreased levels of fasting blood glucose (FBG) (WMD = - 17.17 mg/dl, 95% CI: -26.60, -7.73, I2 = 93.2%), hemoglobin A1c (HbA1c) (WMD = -0.93, 95% CI: - 1.66, -0.17, I2 = 75.0%), C-reactive protein (CRP) (WMD = -1.09 mg/dl, 95% CI: -1.64, -0.53, I2 = 0.0%), triglycerides (WMD = -26.94 mg/dl, 95 % CI = [-52.07, -1.82], P = 0.03, I2 = 90.0%), systolic blood pressure (SBP) (WMD = -5.03 mmHg, 95% CI = -8.15, -1.91, I2 = 0.0%) in comparison to the control groups. UD consumption did not significantly change serum levels of insulin (WMD = 1.07 μU/ml, 95% CI: -1.59, 3.73, I2 = 63.5%), total-cholesterol (WMD = -6.39 mg/dl, 95% CI: -13.84, 1.05, I2 = 0.0%), LDL-cholesterol (LDL-C) (WMD = -1.30 mg/dl, 95% CI: -9.95, 7.35, I2 = 66.1%), HDL-cholesterol (HDL-C) (WMD = 6.95 mg/dl, 95% CI: -0.14, 14.03, I2 = 95.4%), body max index (BMI) (WMD = -0.16 kg/m2, 95% CI: -1.77, 1.44, I2 = 0.0%), and diastolic blood pressure (DBP) (WMD = -1.35 mmHg, 95% CI: -2.86, 0.17, I2= 0.0%) among patients with T2DM.

CONCLUSION

UD consumption may result in an improvement in levels of FBS, HbA1c, CRP, triglycerides, and SBP, but did not affect levels of insulin, total-, LDL-, and HDL-cholesterol, BMI, and DBP in patients with T2DM.

摘要

背景

多项研究探讨了食用荨麻（UD）对2型糖尿病（T2DM）患者代谢谱的影响；然而，研究结果并不一致。本系统评价和临床试验的荟萃分析旨在总结食用UD对T2DM患者代谢谱影响的证据。

方法

通过检索PubMed、Embase、Scopus、Web of Science、Cochrane图书馆和谷歌学术数据库，检索截至2019年12月的合格研究。采用Cochran（Q）和I²统计量检验纳入临床试验的异质性。数据采用固定效应或随机效应模型合并，并表示为加权平均差（WMD）和95%置信区间（CI）。

结果

在1485篇文献中，发现13项临床试验符合当前荟萃分析的条件。与对照组相比，食用UD显著降低了空腹血糖（FBG）水平（WMD=-17.17mg/dl，95%CI：-26.60，-7.73，I²=93.2%）、糖化血红蛋白（HbA1c）水平（WMD=-0.93，95%CI：-1.66，-0.17，I²=75.0%）、C反应蛋白（CRP）水平（WMD=-1.09mg/dl，95%CI：-1.64，-0.53，I²=0.0%）、甘油三酯水平（WMD=-26.94mg/dl，95%CI=[-52.07，-1.82]，P=0.03，I²=90.0%）、收缩压（SBP）水平（WMD=-5.03mmHg，95%CI=-8.15，-1.91，I²=0.0%）。食用UD对T2DM患者的血清胰岛素水平（WMD=1.07μU/ml，95%CI：-1.59，3.73，I²=63.5%）、总胆固醇水平（WMD=-6.39mg/dl，95%CI：-13.84，1.05，I²=0.0%）、低密度脂蛋白胆固醇（LDL-C）水平（WMD=-1.30mg/dl，95%CI：-9.95，7.35，I²=66.1%）高密度脂蛋白胆固醇（HDL-C）水平（WMD=6.95mg/dl，95%CI：-0.14，14.03，I²=95.4%）、体重指数（BMI）（WMD=-0.16kg/m²，CI：-1.77，1.44，I²=0.0%）和舒张压（DBP）水平（WMD=-1.35mmHg，95%CI：-2.86，0.17，I²=0.0%）没有显著影响。