Cobeta Pilar, Pariente Roberto, Osorio Alvaro, Marchan Marta, Cuadrado-Ayuso Marta, Pestaña David, Galindo Julio, Botella-Carretero José I
Department of Anesthesiology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Instituto Ramón y Cajal de Investigación Sanitaria-IRyCIS, 28034 Madrid, Spain.
Biomedicines. 2022 Aug 17;10(8):2000. doi: 10.3390/biomedicines10082000.
Male-obesity-associated secondary hypogonadism (MOSH) is a very prevalent entity that may resolve after marked weight loss. Adiponectin (APN) is an adipokine with anti-inflammatory properties that regulates metabolism. Low-circulating APN is associated with obesity, diabetes, and cardiovascular risk, along with circulating testosterone. We aimed to evaluate APN changes in men with MOSH (low circulating free testosterone (FT) with low or normal gonadotropins) and without it after metabolic surgery. We look for their possible association with cardiovascular risk measured by carotid intima-media thickness (cIMT). We included 60 men (20 submitted to lifestyle modification, 20 to sleeve gastrectomy, and 20 to gastric bypass) evaluated at baseline and 6 months after. The increase in APN at follow-up was reduction in patients with persistent MOSH ( = 10) vs. those without MOSH ( = 30) and MOSH resolution ( = 20), and the former did not achieve a decrease in cIMT. The increase in APN correlated positively with FT (r = 0.320, = 0.013) and inversely with cIMT (r = -0.283, = 0.028). FT inversely correlated with cIMT (r = -0.269, = 0.038). In conclusion, men without MOSH or with MOSH resolution showed a high increase in APN after weight loss with beneficial effects on cIMT. Those without MOSH resolution failed to attain these effects.
男性肥胖相关继发性性腺功能减退（MOSH）是一种非常常见的病症，在显著减重后可能会得到缓解。脂联素（APN）是一种具有抗炎特性的脂肪因子，可调节新陈代谢。低循环水平的APN与肥胖、糖尿病和心血管风险以及循环睾酮水平相关。我们旨在评估代谢手术后患有MOSH（低循环游离睾酮（FT）且促性腺激素水平低或正常）和未患MOSH的男性体内APN的变化。我们探寻它们与通过颈动脉内膜中层厚度（cIMT）测量的心血管风险之间可能存在的关联。我们纳入了60名男性（20名接受生活方式改变，20名接受袖状胃切除术，20名接受胃旁路手术），在基线和术后6个月进行评估。随访时，持续存在MOSH的患者（n = 10）与未患MOSH的患者（n = 30）及MOSH缓解的患者（n = 20）相比，APN的升高幅度较小，且前者的cIMT未降低。APN的升高与FT呈正相关（r = 0.320，P = 0.013），与cIMT呈负相关（r = -0.283，P = 0.028）。FT与cIMT呈负相关（r = -0.269，P = 0.038）。总之，未患MOSH或MOSH得到缓解的男性在减重后APN显著升高，对cIMT有有益影响。而未实现MOSH缓解的男性则未获得这些效果。
