Volodarsky Igor, Anton Anamaria, Zilberman Liaz, Fugenfirov Irina, Neumark Eran, Malnick Stephen, Levy Yair, George Jacob, Goland Sorel
The Heart Institute, Kaplan Medical Center, Hadassah Medical School, Hebrew University, Rehovot 76100, Israel.
Department of Internal Medicine E, Meir Hospital, Kfar 4428164, Israel.
Biology (Basel). 2022 Aug 4;11(8):1168. doi: 10.3390/biology11081168.
(1) Background: Immunoglobulin gamma subclass 4 (IgG4) is a serum protein belonging to the immunoglobulin superfamily. It has a central role in certain immune-mediated conditions defined as IgG4-related disease. There is a paucity of data regarding the potential association of IgG4 and cardiovascular diseases. Our aim is to study the serum levels of IgG4 in patients with ischemic and non-ischemic dilated cardiomyopathy (DCM). (2) Methods: patients with ischemic and non-ischemic DCM were included in this study. Non-ischemic DCM was defined as a left ventricular ejection fraction (LVEF) < 40% without coronary artery disease (CAD). Ischemic DCM was defined as a LVEF < 40% and proven CAD. The serum concentrations of IgG4 were measured by turbidimetry. (3) Results: Overall 98 patients with cardiomyopathy had significantly higher levels of IgG4 compared with the control group (77.4 ± 64.0 vs. 50.3 ± 28.8 mg/dL, p < 0.01). Although there was no difference in the total IgG levels in patients with ischemic DCM, the serum concentrations of IgG4 were significantly higher than the corresponding values in the control group (89.8 ± 67.3 vs. 50.3 ± 28.8 mg/dL; interquartile ranges: 40.4−126.5 vs. 31.8−66.8 mg/dL, p < 0.01). This was altered by gender and smoking. (4) Conclusions: The patients with ischemic DCM had increased serum concentrations of IgG4. Future studies are warranted to explore the potential role of an IgG4-mediated process in patients with heart failure with reduced LVEF.
(1) 背景：免疫球蛋白γ亚类4（IgG4）是一种属于免疫球蛋白超家族的血清蛋白。它在某些被定义为IgG4相关疾病的免疫介导病症中起核心作用。关于IgG4与心血管疾病潜在关联的数据较少。我们的目的是研究缺血性和非缺血性扩张型心肌病（DCM）患者的血清IgG4水平。(2) 方法：本研究纳入了缺血性和非缺血性DCM患者。非缺血性DCM定义为左心室射血分数（LVEF）<40%且无冠状动脉疾病（CAD）。缺血性DCM定义为LVEF<40%且经证实患有CAD。采用比浊法测量血清IgG4浓度。(3) 结果：总体而言，98例心肌病患者的IgG4水平显著高于对照组（77.4±64.0 vs. 50.3±28.8 mg/dL，p<0.01）。尽管缺血性DCM患者的总IgG水平无差异，但血清IgG4浓度显著高于对照组相应值（89.8±67.3 vs. 50.3±28.8 mg/dL；四分位间距：40.4−126.5 vs. 31.8−66.8 mg/dL，p<0.01）。这因性别和吸烟情况而有所改变。(4) 结论：缺血性DCM患者的血清IgG4浓度升高。有必要开展进一步研究以探讨IgG4介导过程在LVEF降低的心力衰竭患者中的潜在作用。
