Ciuca Ioana Mihaiela, Dediu Mihaela, Popin Diana, Pop Liviu Laurentiu, Tamas Liviu Athos, Pilut Ciprian Nicolae, Almajan Guta Bogdan, Popa Zoran Laurentiu
Pediatric Department, University of Medicine and Pharmacy "Victor Babes" Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Pediatric Pulmonology Unit, Clinical County Hospital Timisoara, Evlia Celebi 1-3, 300226 Timisoara, Romania.
Children (Basel). 2022 Aug 20;9(8):1258. doi: 10.3390/children9081258.
In cystic fibrosis (CF), the respiratory disease is the main factor that influences the outcome and the prognosis of patients, bacterial infections being responsible for severe exacerbations. The etiology is often multi-microbial and with resistant strains. The aim of this paper is to present current existing antibiotherapy solutions for CF-associated infections in order to offer a reliable support for individual, targeted, and specific treatment. The inclusion criteria were studies about antibiotherapy in CF pediatric patients. Studies involving adult patients or those with only in vitro results were excluded. The information sources were all articles published until December 2021, in PubMed and ScienceDirect. A total of 74 studies were included, with a total number of 26,979 patients aged between 0-18 years. We approached each pathogen individual, with their specific treatment, comparing treatment solutions proposed by different studies. Preservation of lung function is the main goal of therapy in CF, because once parenchyma is lost, it cannot be recovered. Early personalized intervention and prevention of infection with reputable germs is of paramount importance, even if is an asymmetrical challenge. This research received no external funding.
在囊性纤维化（CF）中，呼吸系统疾病是影响患者结局和预后的主要因素，细菌感染是严重病情加重的原因。其病因通常是多微生物的且存在耐药菌株。本文的目的是介绍目前针对CF相关感染的抗菌治疗方案，以便为个体化、靶向性和特异性治疗提供可靠支持。纳入标准为关于CF儿科患者抗菌治疗的研究。排除涉及成年患者或仅有体外结果的研究。信息来源为截至2021年12月在PubMed和ScienceDirect上发表的所有文章。共纳入74项研究，患者总数为26979名，年龄在0至18岁之间。我们针对每种病原体及其特定治疗方法进行了研究，比较了不同研究提出的治疗方案。保留肺功能是CF治疗的主要目标，因为一旦实质组织丧失，就无法恢复。早期个体化干预以及预防感染知名病菌至关重要，即便这是一项不对称的挑战。本研究未接受外部资助。
