Gunawardana Shannon, Harris Christopher, Greenough Anne
Department of Children's and Women's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RS, UK.
NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, UK.
Children (Basel). 2022 Aug 22;9(8):1267. doi: 10.3390/children9081267.
The forced oscillation technique (FOT) is a non-volitional assessment that is used during tidal breathing. A variant of FOT uses a pseudorandom noise (PRN) signal which we postulated might have utility in assessing lung function in prematurely born children. We, therefore, undertook a systematic review to evaluate the evidence regarding PRN FOT. A comprehensive search of the literature was conducted by using the following databases: Medline, Embase, Web of Science and CINAHL. Observational studies, case series/reports and randomized-controlled trials were eligible for inclusion. Article abstracts and full texts were screened independently by two reviewers, with disagreements resolved by discussion or a third reviewer if necessary. Five studies were included (n = 587 preterm children). Three compared PRN FOT with spirometry, and two compare it to the interrupter technique. Most studies failed to report comprehensive methodology of the frequency spectra used to generate the PRN signal. There was evidence that poorer lung function, as assessed by PRN FOT, was associated with a greater burden of respiratory symptoms, but there was insufficient evidence to determine whether PRN FOT performed better than other lung-function tests. Detailed methodological documentation, in accordance with ERS guidance, is needed to assess the benefits of PRN FOT prior to routine clinical incorporation to assess prematurely born children.
强迫振荡技术（FOT）是一种在潮气呼吸期间进行的非自主性评估。FOT的一种变体使用伪随机噪声（PRN）信号，我们推测该信号可能有助于评估早产儿的肺功能。因此，我们进行了一项系统评价，以评估有关PRN FOT的证据。通过使用以下数据库对文献进行了全面检索：Medline、Embase、科学网和护理学与健康领域数据库。观察性研究、病例系列/报告和随机对照试验均符合纳入标准。文章摘要和全文由两名评审员独立筛选，如有分歧，必要时通过讨论或由第三名评审员解决。纳入了五项研究（n = 587名早产儿）。三项研究将PRN FOT与肺活量测定法进行了比较，两项研究将其与阻断技术进行了比较。大多数研究未能报告用于生成PRN信号的频谱的全面方法。有证据表明，通过PRN FOT评估的较差肺功能与更严重的呼吸道症状负担相关，但没有足够的证据来确定PRN FOT是否比其他肺功能测试表现更好。在将PRN FOT常规纳入临床以评估早产儿之前，需要根据欧洲呼吸学会的指南提供详细的方法学文件，以评估其益处。
