Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern, Dallas, TX 75208, USA.
Department of Internal Medicine, Division of Hematology-Oncology, University of Texas Southwestern, Dallas, TX 75208, USA.
Cells. 2022 Aug 14;11(16):2523. doi: 10.3390/cells11162523.
The Hedgehog signaling pathway is one of the fundamental pathways required for development and regulation of postnatal regeneration in a variety of tissues. The pathway has also been associated with cancers since the identification of a mutation in one of its components, , as the cause of Basal Cell Nevus Syndrome, which is associated with several cancers. Our understanding of the pathway in tumorigenesis has expanded greatly since that initial discovery over two decades ago. The pathway has tumor-suppressive and oncogenic functions depending on the context of the cancer. Furthermore, noncanonical activation of GLI transcription factors has been reported in a number of tumor types. Here, we review the roles of canonical Hedgehog signaling pathway and noncanonical GLI activation in cancers, particularly epithelial cancers, and discuss an emerging concept of the distinct outcomes that these modes have on cancer initiation and progression.
刺猬信号通路是多种组织发育和调节出生后再生所必需的基本通路之一。自其成分之一 中的一个突变被确定为基底细胞痣综合征的病因以来，该通路与癌症也有关联，基底细胞痣综合征与多种癌症相关。自二十多年前的最初发现以来，我们对该通路在肿瘤发生中的理解已经大大扩展。该通路具有肿瘤抑制和致癌功能，具体取决于癌症的具体情况。此外，在许多肿瘤类型中已经报道了非典型 GLI 转录因子的激活。在这里，我们综述了经典刺猬信号通路和非典型 GLI 激活在癌症中的作用，特别是上皮性癌症，并讨论了这些模式对癌症起始和进展的不同影响的一个新兴概念。
