转录组谱分析揭示了帕金森病单卵双胞胎外周血中昼夜行为基因的差异表达。
Transcriptome Profiling Reveals Differential Expression of Circadian Behavior Genes in Peripheral Blood of Monozygotic Twins Discordant for Parkinson's Disease.
机构信息
Institute of Molecular Genetics of National Research Centre, Kurchatov Institute, 2 Kurchatova Sq., 123182 Moscow, Russia.
State Public Health Institution Primorsk Regional Clinical Hospital No. 1, 57 Aleutskaya St., 690091 Vladivostok, Russia.
出版信息
Cells. 2022 Aug 20;11(16):2599. doi: 10.3390/cells11162599.
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Investigating individuals with the most identical genetic background is optimal for minimizing the genetic contribution to gene expression. These individuals include monozygotic twins discordant for PD. Monozygotic twins have the same genetic background, age, sex, and often similar environmental conditions. The aim of this study was to carry out a transcriptome analysis of the peripheral blood of three pairs of monozygotic twins discordant for PD. We identified the metabolic process "circadian behavior" as a priority process for further study. Different expression of genes included in the term "circadian behavior" confirms that this process is involved in PD pathogenesis. We found increased expression of three genes associated with circadian behavior, i.e., , , and , in twins with PD. These genes can be considered as potential candidate genes for this disease.
帕金森病（PD）是最常见的神经退行性疾病之一。研究具有最相似遗传背景的个体是将基因表达中的遗传贡献最小化的最佳方法。这些个体包括 PD 不一致的同卵双胞胎。同卵双胞胎具有相同的遗传背景、年龄、性别，并且通常具有相似的环境条件。本研究的目的是对三对 PD 不一致的同卵双胞胎的外周血进行转录组分析。我们确定代谢过程“昼夜行为”为进一步研究的优先过程。包含在“昼夜行为”一词中的基因的不同表达证实该过程参与 PD 的发病机制。我们发现与昼夜行为相关的三个基因的表达增加，即 、 和 ，在 PD 双胞胎中。这些基因可以被认为是该疾病的潜在候选基因。
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