Olsen T S, Høgenhaven H, Thage O
Neurology. 1987 Jul;37(7):1209-11. doi: 10.1212/wnl.37.7.1209.
Development of epilepsy was studied prospectively in a group of 77 consecutive stroke patients. Included were stroke patients less than 75 years old admitted within the first 3 days after the stroke. Excluded were patients with subarachnoid hemorrhage, vertebrobasilar stroke, and patients with other severe diseases. Cerebral angiography, CT, and EEG were performed in all patients. The patients were followed clinically for 2 to 4 years. Seven patients (9%) developed epilepsy. Of 23 patients with lesions involving the cortex, 6 (26%) developed epilepsy. Of 54 patients in whom the cortex was not involved, only 1 (2%) developed epilepsy. Patients with persisting paresis and cortical involvement seem to be at particularly high risk of developing epilepsy, as 50% of such patients (6 of 12) developed the disease.
对一组连续的77例中风患者进行了癫痫发生情况的前瞻性研究。纳入的是中风后3天内入院的75岁以下中风患者。排除蛛网膜下腔出血、椎基底动脉中风患者以及患有其他严重疾病的患者。所有患者均进行了脑血管造影、CT和脑电图检查。对患者进行了2至4年的临床随访。7例患者(9%)发生了癫痫。在23例有皮质受累病变的患者中,6例(26%)发生了癫痫。在54例皮质未受累的患者中,只有1例(2%)发生了癫痫。持续存在轻瘫且有皮质受累的患者发生癫痫的风险似乎特别高,因为这类患者中有50%(12例中的6例)发生了该病。